All cells in a multicellular organism are constantly exposed to a variety of extracellular signals that they need to interpret and translate into an appropriate response to their environment. These signals can be soluble factors generated locally (for example, synaptic transmission) or distantly (for example, hormones and growth factors), ligands on the surface of other cells, or the extracellular matrix itself. To achieve this, cells maintain a diversity of receptors on their surface that respond specifically to individual stimuli. These receptors fall into families, based primarily on the way in which they generate the intracellular signals that give rise to the particular functional responses. Moreover, the activity of a given receptor can be modulated by other signaling pathways in a variety of ways, generating the flexibility required of such a complex system.  Axon Ligands™ that target receptors are categorized based on the major classification proposed by the IUPAC, incluing G-protein coupled receptors (GPCRs), enzyme linked receptors,  nuclear receptors, sigma receptors, PAQR receptorscytokine receptors, and a number of unclassified receptors (including integrin, thrombopoietin, and nucleotide-binding oligomerization domain-like (NLR) receptors[1].

[1] I.J. Uings, S.N. Farrow. Cell receptors and cell signaling. Mol. Pathol. 2000, 53, 295-299.

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Axon ID Name Description From price
2405 AMG 837 calcium salt Orally bioavailable partial agonist of GPR40 (FFA1) €110.00
2794 AR 420626 GPR41 receptor agonist (FFA3) €95.00
3057 DC260126 GPR40 receptor antagonist (FFA1) €65.00
2582 GSK 137647A Potent and selective FFA4/GPR120 agonist €70.00
2013 GW 9508 GPR40 receptor agonist (FFA1) €85.00
2075 TUG 891 Potent and selective GPR120 (FFA4) agonist €105.00
3078 TUG-1375 Potent GPR43 receptor agonist (FFA2)  Recently added €180.00
2616 ZQ-16 Potent and selective GPR84 agonist that induces phosphorylation of ERK1/2 €95.00

8 Item(s)

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