All cells in a multicellular organism are constantly exposed to a variety of extracellular signals that they need to interpret and translate into an appropriate response to their environment. These signals can be soluble factors generated locally (for example, synaptic transmission) or distantly (for example, hormones and growth factors), ligands on the surface of other cells, or the extracellular matrix itself. To achieve this, cells maintain a diversity of receptors on their surface that respond specifically to individual stimuli. These receptors fall into families, based primarily on the way in which they generate the intracellular signals that give rise to the particular functional responses. Moreover, the activity of a given receptor can be modulated by other signaling pathways in a variety of ways, generating the flexibility required of such a complex system.  Axon Ligands™ that target receptors are categorized based on the major classification proposed by the IUPAC, incluing G-protein coupled receptors (GPCRs), enzyme linked receptors,  nuclear receptors, sigma receptors, PAQR receptorscytokine receptors, and a number of unclassified receptors (including integrin, thrombopoietin, and nucleotide-binding oligomerization domain-like (NLR) receptors[1].

[1] I.J. Uings, S.N. Farrow. Cell receptors and cell signaling. Mol. Pathol. 2000, 53, 295-299.

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Axon ID Name Description From price
1748 Bazedoxifene hydrochloride Selective estrogen receptor modulator (SERM) €70.00
2790 BHPI ER-α antagonist €125.00
1232 DPN Estrogen (ER-β) agonist €70.00
2190 Endoxifen Selective estrogen receptor modulator (SERM) €125.00
2707 Endoxifen hydrochloride Selective estrogen receptor modulator (SERM) €125.00
2221 Endoxifen, (Z)- The more active (Z)-isomer of Endoxifen (SERM; Axon 2190) €155.00
1898 ERB 041 Selective estrogen receptor β (ERβ) agonist €95.00
1926 Estetrol Estrogen receptor agonist, (four- to five-fold preference for the Erα) €95.00
1231 PPT ER-α agonist €95.00
2967 SR 19881 Potent dual agonist of ERRβ/γ €135.00
2051 TSE 424 Selective estrogen receptor modulator (SERM) €80.00
2697 WAY-200070 Brain penetrant ERβ-selective agonist €105.00
2337 XCT 790 ERRα inverse agonist and potent mitochondrial uncoupler €120.00
2652 ZB716 Steroidal, orally bioavailable SERD €125.00

14 Item(s)

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