Receptors

All cells in a multicellular organism are constantly exposed to a variety of extracellular signals that they need to interpret and translate into an appropriate response to their environment. These signals can be soluble factors generated locally (for example, synaptic transmission) or distantly (for example, hormones and growth factors), ligands on the surface of other cells, or the extracellular matrix itself. To achieve this, cells maintain a diversity of receptors on their surface that respond specifically to individual stimuli. These receptors fall into families, based primarily on the way in which they generate the intracellular signals that give rise to the particular functional responses. Moreover, the activity of a given receptor can be modulated by other signaling pathways in a variety of ways, generating the flexibility required of such a complex system.  Axon Ligands™ that target receptors are categorized based on the major classification proposed by the IUPAC, incluing G-protein coupled receptors (GPCRs), enzyme linked receptors,  nuclear receptors, sigma receptors, PAQR receptorscytokine receptors, and a number of unclassified receptors (including integrin, thrombopoietin, and nucleotide-binding oligomerization domain-like (NLR) receptors[1].


[1] I.J. Uings, S.N. Farrow. Cell receptors and cell signaling. Mol. Pathol. 2000, 53, 295-299.

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Axon ID Name Description From price
3040 Abivertinib Potent oral, irreversible, third-generation EGFR TKI with selectivity for mutant EGFRs  Recently added €95.00
1986 AST 1306 tosylate ErbB2 and EGFR inhibitor €105.00
2563 AZD 3759 Potent, orally active, brain-penetrant, EGFR tyrosine kinase inhibitor €85.00
2342 AZD 9291 Potent oral, irreversible, third-generation EGFR TKI with selectivity for mutant EGFRs €95.00
1433 CI 1033 EGFR tyrosine kinase inhibitor €60.00
2680 EAI045 Allosteric EGFR inhibitor (L858R/T790M-specific) €105.00
1760 EGFR Inhibitor [879127-07-8] Highly selective EGFR tyrosine kinase inhibitor €125.00
1128 Erlotinib hydrochloride EGFR tyrosine kinase inhibitor €70.00
1393 Gefitinib EGFR tyrosine kinase inhibitor €70.00
2955 NSC 228155 EGFR tyrosine kinase activator; Inhibitor of KIX-KID interaction €75.00
1632 OSI 420 EGFR tyrosine kinase inhibitor €90.00
1665 Pelitinib EGFR tyrosine kinase inhibitor €95.00
2053 TAK 165 ErbB2/HER2 kinase inhibitor €65.00
1506 WZ 4002 EGFR kinase inhibitor (T790M specific) €70.00

14 Item(s)

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