All cells in a multicellular organism are constantly exposed to a variety of extracellular signals that they need to interpret and translate into an appropriate response to their environment. These signals can be soluble factors generated locally (for example, synaptic transmission) or distantly (for example, hormones and growth factors), ligands on the surface of other cells, or the extracellular matrix itself. To achieve this, cells maintain a diversity of receptors on their surface that respond specifically to individual stimuli. These receptors fall into families, based primarily on the way in which they generate the intracellular signals that give rise to the particular functional responses. Moreover, the activity of a given receptor can be modulated by other signaling pathways in a variety of ways, generating the flexibility required of such a complex system.  Axon Ligands™ that target receptors are categorized based on the major classification proposed by the IUPAC, incluing G-protein coupled receptors (GPCRs), enzyme linked receptors,  nuclear receptors, sigma receptors, PAQR receptorscytokine receptors, and a number of unclassified receptors (including integrin, thrombopoietin, and nucleotide-binding oligomerization domain-like (NLR) receptors[1].

[1] I.J. Uings, S.N. Farrow. Cell receptors and cell signaling. Mol. Pathol. 2000, 53, 295-299.

15 Item(s)

per page
Axon ID Name Description From price
1179 A1B1 hydrochloride CCR1 antagonist €125.00
1738 AMD 3100 CXCR4 antagonist €85.00
1930 AMD 3465 hexahydrobromide Potent and selective CXCR4 antagonist €85.00
2842 AZD 2098 Potent, selective and bioavailable CCR4 receptor antagonist €125.00
2255 AZD 8797 Potent and selective antagonist of the Fractalkine receptor (FKN or CX3CR1) €120.00
2082 BX 471 Selective CCR1 receptor antagonist €105.00
2665 Cenicriviroc Oral CCR5-antagonist for treatment of HIV infection €145.00
1800 CXCR3 Antagonist 6c CXCR3 antagonist €135.00
2921 LIT-927 Selective, locally and orally active CXCL12 neutraligand €95.00
1559 SB 265610 CXCR2 antagonist €95.00
2593 SB 332235 Nonpeptide CXCR2 antagonist exhibiting significant anti-inflammatory effects €105.00
2685 Vercirnon CCR9 antagonist €135.00
1620 WZ 811 CXCR4 antagonist €80.00
2636 YJC-10592 CCR2 antagonist €145.00
2861 ZK 756326 dihydrochloride CCR8 agonist €90.00

15 Item(s)

per page
Please wait...