Receptors

All cells in a multicellular organism are constantly exposed to a variety of extracellular signals that they need to interpret and translate into an appropriate response to their environment. These signals can be soluble factors generated locally (for example, synaptic transmission) or distantly (for example, hormones and growth factors), ligands on the surface of other cells, or the extracellular matrix itself. To achieve this, cells maintain a diversity of receptors on their surface that respond specifically to individual stimuli. These receptors fall into families, based primarily on the way in which they generate the intracellular signals that give rise to the particular functional responses. Moreover, the activity of a given receptor can be modulated by other signaling pathways in a variety of ways, generating the flexibility required of such a complex system.  Axon Ligands™ that target receptors are categorized based on the major classification proposed by the IUPAC, incluing G-protein coupled receptors (GPCRs), enzyme linked receptors,  nuclear receptors, sigma receptors, PAQR receptorscytokine receptors, and a number of unclassified receptors (including integrin, thrombopoietin, and nucleotide-binding oligomerization domain-like (NLR) receptors[1].


[1] I.J. Uings, S.N. Farrow. Cell receptors and cell signaling. Mol. Pathol. 2000, 53, 295-299.

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Axon ID Name Description From price
1218 AM 251 CB1 antagonist €95.00
1219 AM 281 CB1 antagonist €95.00
2791 AM 4113 CB1 antagonist €105.00
2541 APD 597 Orally bioavailable selective GPR119 agonist €125.00
2380 APD 668 Potent and selective, orally active GPR119 agonist €125.00
1572 AR 231453 Cannabinoid GPR119 agonist €85.00
1234 Cannabidiol GPR55 antagonist €105.00
1235 Cannabidiol, Abnormal Cannabinoid agonist €135.00
2015 CP 945598 CB1 antagonist €135.00
2119 CP 945598 hydrochloride CB1 antagonist €135.00
1925 GW 842166X Cannabinoid CB2 receptor agonist €110.00
1440 HU 308 CB2 agonist €135.00
1574 Iodopravadoline CB2 antagonist €75.00
1418 JWH 133 CB2 agonist €95.00
2092 MBX 2982 Potent and selective GPR119 agonist €125.00

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