All cells in a multicellular organism are constantly exposed to a variety of extracellular signals that they need to interpret and translate into an appropriate response to their environment. These signals can be soluble factors generated locally (for example, synaptic transmission) or distantly (for example, hormones and growth factors), ligands on the surface of other cells, or the extracellular matrix itself. To achieve this, cells maintain a diversity of receptors on their surface that respond specifically to individual stimuli. These receptors fall into families, based primarily on the way in which they generate the intracellular signals that give rise to the particular functional responses. Moreover, the activity of a given receptor can be modulated by other signaling pathways in a variety of ways, generating the flexibility required of such a complex system.  Axon Ligands™ that target receptors are categorized based on the major classification proposed by the IUPAC, incluing G-protein coupled receptors (GPCRs), enzyme linked receptors,  nuclear receptors, sigma receptors, PAQR receptorscytokine receptors, and a number of unclassified receptors (including integrin, thrombopoietin, and nucleotide-binding oligomerization domain-like (NLR) receptors[1].

[1] I.J. Uings, S.N. Farrow. Cell receptors and cell signaling. Mol. Pathol. 2000, 53, 295-299.

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Axon ID Name Description From price
2191 AR 244555 Inverse agonist of Mas G-protein signaling €125.00
3104 Candesartan cilexetil Potent and highly specific AT2 receptor antagonist €50.00
3102 Losartan Non-peptide, potent and orally active angiotensin II receptor antagonist €60.00
1969 M 24 First non-peptide selective AT2 receptor agonist Inquire
1276 PD 123319 ditrifluoroacetate AT2 antagonist €95.00
3103 Telmisartan Non-peptide, highly potent and selective AT1 receptor antagonist €60.00
3106 Valsartan Potent, highly selective, and orally active AT1 antagonist €76.00

7 Item(s)

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