All cells in a multicellular organism are constantly exposed to a variety of extracellular signals that they need to interpret and translate into an appropriate response to their environment. These signals can be soluble factors generated locally (for example, synaptic transmission) or distantly (for example, hormones and growth factors), ligands on the surface of other cells, or the extracellular matrix itself. To achieve this, cells maintain a diversity of receptors on their surface that respond specifically to individual stimuli. These receptors fall into families, based primarily on the way in which they generate the intracellular signals that give rise to the particular functional responses. Moreover, the activity of a given receptor can be modulated by other signaling pathways in a variety of ways, generating the flexibility required of such a complex system.  Axon Ligands™ that target receptors are categorized based on the major classification proposed by the IUPAC, incluing G-protein coupled receptors (GPCRs), enzyme linked receptors,  nuclear receptors, sigma receptors, PAQR receptorscytokine receptors, and a number of unclassified receptors (including integrin, thrombopoietin, and nucleotide-binding oligomerization domain-like (NLR) receptors[1].

[1] I.J. Uings, S.N. Farrow. Cell receptors and cell signaling. Mol. Pathol. 2000, 53, 295-299.

15 Item(s)

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Axon ID Name Description From price
1371 Atipamezole hydrochloride α2 adrenoceptor antagonist €95.00
1154 B-HT 933 dihydrochloride α2 adrenoceptor agonist €115.00
1555 Brimonidine tartrate α2 adrenoceptor agonist €95.00
1157 Bromobuterol β2 agonist €85.00
1159 Celiprolol hydrochloride β1 antagonist €135.00
3044 Clonidine hydrochloride α2 adrenoceptor agonist  Recently added €60.00
3065 Dexmedetomidine hydrochloride Selective α2 adrenoceptor agonist  Recently added €75.00
1155 Efaroxan hydrochloride α2 adrenoceptor antagonist €65.00
3066 Medetomidine hydrochloride Potent and selective α2 adrenoceptor agonist  Recently added €70.00
2414 Mirabegron Highly selective and orally active agonist of the human β3-adrenoceptor €135.00
1296 Modafinil α1 adrenoceptor agonist €55.00
2040 Prazosin hydrochloride Peripherally acting α1 adrenoceptor antagonist €50.00
1290 ST 91 α2 adrenoceptor agonist €80.00
2579 TAK 259 Selective and orally active α1D adrenoceptor antagonist €95.00
1518 Timolol maleate β1 adrenergic antagonist €105.00

15 Item(s)

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