Receptors

All cells in a multicellular organism are constantly exposed to a variety of extracellular signals that they need to interpret and translate into an appropriate response to their environment. These signals can be soluble factors generated locally (for example, synaptic transmission) or distantly (for example, hormones and growth factors), ligands on the surface of other cells, or the extracellular matrix itself. To achieve this, cells maintain a diversity of receptors on their surface that respond specifically to individual stimuli. These receptors fall into families, based primarily on the way in which they generate the intracellular signals that give rise to the particular functional responses. Moreover, the activity of a given receptor can be modulated by other signaling pathways in a variety of ways, generating the flexibility required of such a complex system.  Axon Ligands™ that target receptors are categorized based on the major classification proposed by the IUPAC, incluing G-protein coupled receptors (GPCRs), enzyme linked receptors,  nuclear receptors, sigma receptors, PAQR receptorscytokine receptors, and a number of unclassified receptors (including integrin, thrombopoietin, and nucleotide-binding oligomerization domain-like (NLR) receptors[1].


[1] I.J. Uings, S.N. Farrow. Cell receptors and cell signaling. Mol. Pathol. 2000, 53, 295-299.

15 Item(s)

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Axon ID Name Description From price
1188 Adenosine amine congener Adenosine A1 agonist €125.00
2317 BAY 60-6583 Potent and highly selective A2BAR (Adenosine) agonist €125.00
1319 CGS 21680 hydrochloride Adenosine A2A agonist €95.00
1190 Chloroadenosine, 2- Adenosine A1 and A2A agonist €65.00
1287 GR 79236 Adenosine A1 agonist €120.00
1423 KW 6002 Adenosine A2A antagonist €85.00
2076 MRS 1523 Adenosine A3 receptor antagonist €120.00
1603 Rolofylline Adenosine A1 antagonist €85.00
1852 Rolofylline metabolite M1-cis Adenosine A1 antagonist €105.00
1851 Rolofylline metabolite M1-trans Adenosine A1 antagonist €105.00
1264 SCH 442416 Adenosine A2A antagonist €90.00
2283 SCH 442416, Desmethyl Radioligand precursor of the adenosine A2A antagonist SCH 442416 €300.00
1253 SCH 58261 Adenosine A2A antagonist €90.00
1265 SDZ-WAG 994 Adenosine A1 agonist €125.00
1193 UK 432097 Adenosine A2A agonist €135.00

15 Item(s)

per page
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