All cells in a multicellular organism are constantly exposed to a variety of extracellular signals that they need to interpret and translate into an appropriate response to their environment. These signals can be soluble factors generated locally (for example, synaptic transmission) or distantly (for example, hormones and growth factors), ligands on the surface of other cells, or the extracellular matrix itself. To achieve this, cells maintain a diversity of receptors on their surface that respond specifically to individual stimuli. These receptors fall into families, based primarily on the way in which they generate the intracellular signals that give rise to the particular functional responses. Moreover, the activity of a given receptor can be modulated by other signaling pathways in a variety of ways, generating the flexibility required of such a complex system.  Axon Ligands™ that target receptors are categorized based on the major classification proposed by the IUPAC, incluing G-protein coupled receptors (GPCRs), enzyme linked receptors,  nuclear receptors, sigma receptors, PAQR receptorscytokine receptors, and a number of unclassified receptors (including integrin, thrombopoietin, and nucleotide-binding oligomerization domain-like (NLR) receptors[1].

[1] I.J. Uings, S.N. Farrow. Cell receptors and cell signaling. Mol. Pathol. 2000, 53, 295-299.

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Axon ID Name Description From price
2796 Clozapine N-oxide Muscarinic DREADD agonist €85.00
1289 GMC 1-109 Clozapine analog devoid of DA, 5-HT2, H1 and α1 affinities, but with high M1 affinity €125.00
1679 MDL 201012 Muscarinic M3 antagonist €110.00
3286 Penehyclidine hydrochloride Anticholinergic drug €130.00
2463 TBPB Allosteric activator of the M1 acetylcholine receptor devoid of M2-M5 activity. €105.00
2049 Tolterodine L-tartrate Muscarinic receptor (mAChR) antagonist €60.00
1988 VU 0029767 PAM of mAChR M1 that potentiates the agonistic effect of Ach €110.00
1483 VU 0152100 PAM of M4 mAChR €85.00
1786 VU 0238429 Selective PAM of M5 mAChR (CHRM5) €105.00
1787 VU 0255035 Selective M1 mAChR Antagonist €120.00
1703 VU 0357017 hydrochloride PAM of M1 mAChR €115.00
1943 VU 0365114 Selective PAM of M5 mAChR (CHRM5) €115.00
2739 VU 6008667 Selective NAM of M5 mAChR (CHRM5) €105.00
3271 VU0486846 Potent and highly selective PAM of M1 mAChR €165.00
1273 Zamifenacin fumarate Muscarinic M3 antagonist €115.00

15 Item(s)

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