Receptors

All cells in a multicellular organism are constantly exposed to a variety of extracellular signals that they need to interpret and translate into an appropriate response to their environment. These signals can be soluble factors generated locally (for example, synaptic transmission) or distantly (for example, hormones and growth factors), ligands on the surface of other cells, or the extracellular matrix itself. To achieve this, cells maintain a diversity of receptors on their surface that respond specifically to individual stimuli. These receptors fall into families, based primarily on the way in which they generate the intracellular signals that give rise to the particular functional responses. Moreover, the activity of a given receptor can be modulated by other signaling pathways in a variety of ways, generating the flexibility required of such a complex system.  Axon Ligands™ that target receptors are categorized based on the major classification proposed by the IUPAC, incluing G-protein coupled receptors (GPCRs), enzyme linked receptors,  nuclear receptors, sigma receptors, PAQR receptorscytokine receptors, and a number of unclassified receptors (including integrin, thrombopoietin, and nucleotide-binding oligomerization domain-like (NLR) receptors[1].


[1] I.J. Uings, S.N. Farrow. Cell receptors and cell signaling. Mol. Pathol. 2000, 53, 295-299.

9 Item(s)

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Axon ID Name Description From price
2153 AZD 3463 Potent inhibitor of ALK and IGF1R €105.00
2978 Brigatinib Potent, selective, and orally active anaplastic lymphoma kinase (ALK) inhibitor €80.00
1884 CH 5424802 Orally available and selective ALK inhibitor €95.00
2915 CID 1375606 Selective surrogate agonist for GPR27 €95.00
2569 JNJ 63533054 Potent, brain-penetrant, selective agonist of GPR139 €90.00
2224 LDK 378 Potent, bioavailable, and selective anaplastic lymphoma kinase (ALK) inhibitor €95.00
2609 NCRW0005-F05 GPR139 antagonist; useful tool to study GPR139 pharmacology €125.00
1892 NM-PP1, 1- Potent tyrosine kinase inhibitor (TKI) of multiple targets (Src, Fyn, Abl, CDK, Trk) €95.00
2600 PF 06463922 Potent, orally available and brain-penetrant ALK/ROS1 selective inhibitor €105.00

9 Item(s)

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