All cells in a multicellular organism are constantly exposed to a variety of extracellular signals that they need to interpret and translate into an appropriate response to their environment. These signals can be soluble factors generated locally (for example, synaptic transmission) or distantly (for example, hormones and growth factors), ligands on the surface of other cells, or the extracellular matrix itself. To achieve this, cells maintain a diversity of receptors on their surface that respond specifically to individual stimuli. These receptors fall into families, based primarily on the way in which they generate the intracellular signals that give rise to the particular functional responses. Moreover, the activity of a given receptor can be modulated by other signaling pathways in a variety of ways, generating the flexibility required of such a complex system.  Axon Ligands™ that target receptors are categorized based on the major classification proposed by the IUPAC, incluing G-protein coupled receptors (GPCRs), enzyme linked receptors,  nuclear receptors, sigma receptors, PAQR receptorscytokine receptors, and a number of unclassified receptors (including integrin, thrombopoietin, and nucleotide-binding oligomerization domain-like (NLR) receptors[1].

[1] I.J. Uings, S.N. Farrow. Cell receptors and cell signaling. Mol. Pathol. 2000, 53, 295-299.

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Axon ID Name Description From price
2898 AC 264613 Potent, selective, and metabolically stable PAR2 agonist €95.00
2030 E 5555 hydrobromide Potent and orally active PAR1 antagonist €115.00
1622 GB 83 PAR2 antagonist €110.00
3043 I-191 Potent PAR2 antagonist €175.00
1928 ML 161 Allosteric inhibitor of PAR1 €90.00
2055 Q94 hydrochloride Negative allosteric modulator of PAR1 (Gαq linkage) €80.00
1755 SCH 530348 PAR1 antagonist €135.00
1275 SCH 79797 dihydrochloride PAR1 antagonist €90.00

8 Item(s)

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