Receptors

All cells in a multicellular organism are constantly exposed to a variety of extracellular signals that they need to interpret and translate into an appropriate response to their environment. These signals can be soluble factors generated locally (for example, synaptic transmission) or distantly (for example, hormones and growth factors), ligands on the surface of other cells, or the extracellular matrix itself. To achieve this, cells maintain a diversity of receptors on their surface that respond specifically to individual stimuli. These receptors fall into families, based primarily on the way in which they generate the intracellular signals that give rise to the particular functional responses. Moreover, the activity of a given receptor can be modulated by other signaling pathways in a variety of ways, generating the flexibility required of such a complex system.  Axon Ligands™ that target receptors are categorized based on the major classification proposed by the IUPAC, incluing G-protein coupled receptors (GPCRs), enzyme linked receptors,  nuclear receptors, sigma receptors, PAQR receptorscytokine receptors, and a number of unclassified receptors (including integrin, thrombopoietin, and nucleotide-binding oligomerization domain-like (NLR) receptors[1].


[1] I.J. Uings, S.N. Farrow. Cell receptors and cell signaling. Mol. Pathol. 2000, 53, 295-299.

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Axon ID Name Description From price
1143 Aripiprazole Atypical antipsychotic €75.00
1503 Asenapine maleate Atypical antipsychotic €75.00
1508 Bifeprunox mesylate D2 agonist; 5-HT1A agonist €75.00
1146 Clozapine Atypical antipsychotic €45.00
2846 Clozapine, N-Desmethyl- Metabolite of Clozapine €90.00
1151 GMC 1-116 Clozapine analogue €125.00
1148 GMC 1-169 Atypical antipsychotic €145.00
1150 GMC 2-83 Atypical antipsychotic €145.00
1149 GMC 61-39 Atypical antipsychotic Inquire
1493 Iloperidone Atypical antipsychotic €85.00
1147 Isoclozapine Typical antipsychotic €135.00
1298 Olanzapine Atypical antipsychotic €75.00
1354 Quetiapine fumarate Atypical antipsychotic €75.00
1454 Risperidone Atypical antipsychotic €75.00
1236 SKF 83566 hydrobromide D1 antagonist €70.00

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