Receptors

All cells in a multicellular organism are constantly exposed to a variety of extracellular signals that they need to interpret and translate into an appropriate response to their environment. These signals can be soluble factors generated locally (for example, synaptic transmission) or distantly (for example, hormones and growth factors), ligands on the surface of other cells, or the extracellular matrix itself. To achieve this, cells maintain a diversity of receptors on their surface that respond specifically to individual stimuli. These receptors fall into families, based primarily on the way in which they generate the intracellular signals that give rise to the particular functional responses. Moreover, the activity of a given receptor can be modulated by other signaling pathways in a variety of ways, generating the flexibility required of such a complex system.  Axon Ligands™ that target receptors are categorized based on the major classification proposed by the IUPAC, incluing G-protein coupled receptors (GPCRs), enzyme linked receptors,  nuclear receptors, sigma receptors, PAQR receptorscytokine receptors, and a number of unclassified receptors (including integrin, thrombopoietin, and nucleotide-binding oligomerization domain-like (NLR) receptors[1].


[1] I.J. Uings, S.N. Farrow. Cell receptors and cell signaling. Mol. Pathol. 2000, 53, 295-299.

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Axon ID Name Description From price
2811 25CN-NBOH hydrochloride Selective brain penetrant 5-HT2A receptor agonist €145.00
1575 5-HT6 antagonist 29 Selective brain penetrant 5-HT6 receptor antagonist €90.00
1058 Aminotetraline hydrochloride, (R)-(+)-8-Methoxy-2- Building Block; 5-HT1A agonist Inquire
1059 Aminotetraline hydrochloride, (S)-(-)-8-Methoxy-2- Building Block; 5-HT1A agonist Inquire
1057 Aminotetraline hydrochloride, 8-Methoxy-2- Building Block; 5-HT1A agonist Inquire
2353 Blonanserin Potent dopamine D2 and serotonin 5-HT2 antagonist €65.00
2335 Brexpiprazole dihydrochloride Drug candidate with high affinity for 5-HT1A, 5-HT2A, D2L, α1B, and α2C-adrenergic receptors €135.00
1995 Buspirone hydrochloride 5-HT1A partial agonist €50.00
1206 CGS 12066B 5-HT1B agonist €75.00
1068 Chloro-DPAT hydrochloride, 6- Bioactive tetralin derivative €105.00
2102 CP 135807 Selective 5-HT1D receptor agonist €75.00
1945 CP 94253 hydrochloride Potent and selective serotonin 5-HT1B receptor agonist €105.00
2750 DU125530 5-HT1A antagonist €105.00
2050 Eletriptan hydrobromide Selective 5-HT1B/1D receptor agonist €90.00
1142 Eltoprazine hydrochloride 5-HT1A and 5-HT1B agonist €82.00

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