All cells in a multicellular organism are constantly exposed to a variety of extracellular signals that they need to interpret and translate into an appropriate response to their environment. These signals can be soluble factors generated locally (for example, synaptic transmission) or distantly (for example, hormones and growth factors), ligands on the surface of other cells, or the extracellular matrix itself. To achieve this, cells maintain a diversity of receptors on their surface that respond specifically to individual stimuli. These receptors fall into families, based primarily on the way in which they generate the intracellular signals that give rise to the particular functional responses. Moreover, the activity of a given receptor can be modulated by other signaling pathways in a variety of ways, generating the flexibility required of such a complex system.  Axon Ligands™ that target receptors are categorized based on the major classification proposed by the IUPAC, incluing G-protein coupled receptors (GPCRs), enzyme linked receptors,  nuclear receptors, sigma receptors, PAQR receptorscytokine receptors, and a number of unclassified receptors (including integrin, thrombopoietin, and nucleotide-binding oligomerization domain-like (NLR) receptors[1].

[1] I.J. Uings, S.N. Farrow. Cell receptors and cell signaling. Mol. Pathol. 2000, 53, 295-299.

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Axon ID Name Description From price
2948 AM 580 RAR-α agonist €95.00
2679 AR7 RARα antagonist that stimulates chaperone-mediated autophagy €90.00
1700 Bexarotene Retinoid X Receptor antagonist €65.00
1194 BMS 189961 RAR-γ agonist €145.00
1173 BMS 270394 RAR-γ agonist €165.00
2964 CD12681 Potent RORγ inverse agonist €135.00
1241 CH 55 RAR agonist €90.00
3003 HX600 RXR-Nurr1 heterodimer complex agonist €145.00
1242 LE 135 RAR antagonist €95.00
2637 LY 2955303 dihydrochloride Potent and selective RARγ antagonist for the treatment of osteoarthritis pain €145.00
2408 NRX 194204 Highly potent and specific RXR agonist devoid of any RAR activity €105.00
2902 QX77 Chaperone-mediated autophagy (CMA) activator €120.00
3321 Retinoic acid RAR ligand  Recently added €50.00

13 Item(s)

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