All cells in a multicellular organism are constantly exposed to a variety of extracellular signals that they need to interpret and translate into an appropriate response to their environment. These signals can be soluble factors generated locally (for example, synaptic transmission) or distantly (for example, hormones and growth factors), ligands on the surface of other cells, or the extracellular matrix itself. To achieve this, cells maintain a diversity of receptors on their surface that respond specifically to individual stimuli. These receptors fall into families, based primarily on the way in which they generate the intracellular signals that give rise to the particular functional responses. Moreover, the activity of a given receptor can be modulated by other signaling pathways in a variety of ways, generating the flexibility required of such a complex system.  Axon Ligands™ that target receptors are categorized based on the major classification proposed by the IUPAC, incluing G-protein coupled receptors (GPCRs), enzyme linked receptors,  nuclear receptors, sigma receptors, PAQR receptorscytokine receptors, and a number of unclassified receptors (including integrin, thrombopoietin, and nucleotide-binding oligomerization domain-like (NLR) receptors[1].

[1] I.J. Uings, S.N. Farrow. Cell receptors and cell signaling. Mol. Pathol. 2000, 53, 295-299.

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Axon ID Name Description From price
2468 ANA 12 Selective TrkB antagonist with anxiolytic and antidepressant activity in mice €90.00
1610 AZ 23 TrkA and TrkB inhibitor €80.00
2089 Dihydroxyflavone, 7,8- Tyrosine kinase receptor B (TrkB) agonist €55.00
2248 GNF 5837 Potent, selective, and orally bioavailable tropomyosin receptor kinase (Trk) inhibitor €90.00
1251 GW 441756 TrkA inhibitor €75.00
3407 LOXO-101 sulfate First-in-class, potent, highly selective and ATP-competitive TRK inhibitor  Recently added €80.00
2174 PD 90780 Inhibitor of NGFs binding to the P75 NGFR €95.00

7 Item(s)

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