Receptors

All cells in a multicellular organism are constantly exposed to a variety of extracellular signals that they need to interpret and translate into an appropriate response to their environment. These signals can be soluble factors generated locally (for example, synaptic transmission) or distantly (for example, hormones and growth factors), ligands on the surface of other cells, or the extracellular matrix itself. To achieve this, cells maintain a diversity of receptors on their surface that respond specifically to individual stimuli. These receptors fall into families, based primarily on the way in which they generate the intracellular signals that give rise to the particular functional responses. Moreover, the activity of a given receptor can be modulated by other signaling pathways in a variety of ways, generating the flexibility required of such a complex system.  Axon Ligands™ that target receptors are categorized based on the major classification proposed by the IUPAC, incluing G-protein coupled receptors (GPCRs), enzyme linked receptors,  nuclear receptors, sigma receptors, PAQR receptorscytokine receptors, and a number of unclassified receptors (including integrin, thrombopoietin, and nucleotide-binding oligomerization domain-like (NLR) receptors[1].


[1] I.J. Uings, S.N. Farrow. Cell receptors and cell signaling. Mol. Pathol. 2000, 53, 295-299.

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Axon ID Name Description From price
2340 AZ-GHS-22 Orally available Ghrelin receptor (GHS-R1a) inverse agonist €160.00
2114 CP 775146 Potent and selective PPARα agonist €85.00
2147 CpdD hydrochloride Ghrelin receptor (GhrR aka GHSR-1a) antagonist €135.00
2727 Elafibranor Dual PPARα/δ agonist  Recently added €90.00
2686 FH535 Dual inhibitor of PPAR and Wnt/β-catenin signaling €75.00
2706 FH535 sodium salt Dual inhibitor of PPAR and Wnt/β-catenin signaling €80.00
2363 GSK 2033 The first potent cell-active LXR antagonist €105.00
1628 GSK 3787 PPARδ antagonist €90.00
1266 GW 3965 hydrochloride Liver X receptor agonist €95.00
1237 GW 7647 PPARα agonist €95.00
2262 GW 9662 Selective PPARγ antagonist €60.00
2019 INT 131 Selective PPARγ modulator (partial agonist) €125.00
1567 KRP 297 PPARα agonist; PPARγ agonist €95.00
2357 LXR 623 Partial agonist of Liver X Receptor €95.00
2402 MHY 908 Dual PPARα/γ agonist, and potent inhibitor of mushroom tyrosinase €95.00

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