Receptors

All cells in a multicellular organism are constantly exposed to a variety of extracellular signals that they need to interpret and translate into an appropriate response to their environment. These signals can be soluble factors generated locally (for example, synaptic transmission) or distantly (for example, hormones and growth factors), ligands on the surface of other cells, or the extracellular matrix itself. To achieve this, cells maintain a diversity of receptors on their surface that respond specifically to individual stimuli. These receptors fall into families, based primarily on the way in which they generate the intracellular signals that give rise to the particular functional responses. Moreover, the activity of a given receptor can be modulated by other signaling pathways in a variety of ways, generating the flexibility required of such a complex system.  Axon Ligands™ that target receptors are categorized based on the major classification proposed by the IUPAC, incluing G-protein coupled receptors (GPCRs), enzyme linked receptors,  nuclear receptors, sigma receptors, PAQR receptorscytokine receptors, and a number of unclassified receptors (including integrin, thrombopoietin, and nucleotide-binding oligomerization domain-like (NLR) receptors[1].


[1] I.J. Uings, S.N. Farrow. Cell receptors and cell signaling. Mol. Pathol. 2000, 53, 295-299.

8 Item(s)

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Axon ID Name Description From price
1916 AMG 208 Inhibitor of c-MET receptor tyrosine kinase (RTK) €110.00
1838 ARQ 197 c-MET tyrosine kinase Inhibitor €95.00
1582 Foretinib c-MET and VEGFR2 tyrosine kinase inhibitor €90.00
2553 LY 2801653 Orally bioavailable multi-kinase inhibitor with potent activity against c-MET €120.00
1660 PF 02341066 c-MET Inhibitor; NPM-ALK inhibitor €80.00
1583 PF 04217903 mesylate c-MET tyrosine kinase Inhibitor €80.00
1914 SGX 523 ATP-competitive inhibitor of c-MET €120.00
1581 SU 11274 ATP-competitive inhibitor of c-MET €95.00

8 Item(s)

per page
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