Receptors

All cells in a multicellular organism are constantly exposed to a variety of extracellular signals that they need to interpret and translate into an appropriate response to their environment. These signals can be soluble factors generated locally (for example, synaptic transmission) or distantly (for example, hormones and growth factors), ligands on the surface of other cells, or the extracellular matrix itself. To achieve this, cells maintain a diversity of receptors on their surface that respond specifically to individual stimuli. These receptors fall into families, based primarily on the way in which they generate the intracellular signals that give rise to the particular functional responses. Moreover, the activity of a given receptor can be modulated by other signaling pathways in a variety of ways, generating the flexibility required of such a complex system.  Axon Ligands™ that target receptors are categorized based on the major classification proposed by the IUPAC, incluing G-protein coupled receptors (GPCRs), enzyme linked receptors,  nuclear receptors, sigma receptors, PAQR receptorscytokine receptors, and a number of unclassified receptors (including integrin, thrombopoietin, and nucleotide-binding oligomerization domain-like (NLR) receptors[1].


[1] I.J. Uings, S.N. Farrow. Cell receptors and cell signaling. Mol. Pathol. 2000, 53, 295-299.

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Axon ID Name Description From price
1419 AB 1010 PDGFR, c-KIT and FGFR3 tyrosine kinase inhibitor €70.00
1638 ABT 869 PDGFR, c-KIT and VEGFR tyrosine kinase inhibitor €85.00
1696 AC 220 dihydrochloride FLT3 inhibitor €90.00
1653 AEE 788 EGFR, ErbB2 and VEGFR tyrosine kinase inhibitor €95.00
1414 AG 013736 PDGFR,c-KIT and VEGFR tyrosine kinase inhibitor €75.00
1916 AMG 208 Inhibitor of c-MET receptor tyrosine kinase (RTK) €110.00
1768 AMG 706 Multiple receptor tyrosine kinase inhibitor €105.00
2368 Amuvatinib RTK inhibitor which effectively inhibits PDGFR, c-Kit and c-Met €105.00
1369 Apilimod Cytokine inhibitor; IL-12 and IL-23 inhibitor Inquire
2500 Apilimod mesylate Cytokine inhibitor; IL-12 and IL-23 inhibitor Inquire
1838 ARQ 197 c-MET tyrosine kinase Inhibitor €95.00
1986 AST 1306 tosylate ErbB2 and EGFR inhibitor €105.00
2692 AX-024 hydrochloride T cell receptor inhibitor €125.00
1610 AZ 23 TrkA and TrkB inhibitor €90.00
2153 AZD 3463 Potent inhibitor of ALK and IGF1R €105.00

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