PAQR

Membrane bound Progesteron Receptors (mPRs, PAQR receptor family) are 7-TM proteins expressed on the plasma membranes of cells and bind progestins in a specific, displaceable, high affinity, limited capacity manner, characteristic of steroid membrane receptors and activate G-proteins in several cell types. The mPRs however, do not belong to the GPCR superfamily, nore do they belong to the family of nuclear receptors N3RC like the progesterone receptor (PR). In contrast, mPRs are members of the progestin and adipoQ receptor (PAQR) family. Noteworthy, the Axon ligands™ DiMNF and Stemregenin 1 (Axon 1935 and Axon 1865, respectively) modulating the activity of the aryl hydrocarbon receptor (AHR) are listed and discussed in the section of transcription factors as well, since their biological target has been defined as a class 1 transcription factor[1].  


[1] V. Sauzeau et al. Receptor (Ahr) Controls Cardiovascular and Respiratory Functions by Regulating the Expression of the Vav3 Proto-oncogene. J. Biol. Chem. 2011, 286, 2896-2909.

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Axon ID Name Description From price
2085 Org OD 02-0 Selective agonist of membrane progesterone receptor (mPR) €120.00
2275 AdipoRon Orally active small-molecule AdipoR agonist €80.00

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