Nurr
NR4A family orphan nuclear receptors are an important class of transcription factors for development and homeostasis of dopaminergic neurons that also inhibit expression of inflammatory genes in glial cells[1]. Nur77 (NGIF-B/NR4A1), Nurr1 (NOT/NR4A2), and NOR-1 (MINOR/NR4A3) form a family of orphan nuclear receptors with a highly conserved DNA-binding domain and COOH-terminal ligand-binding domain, but minimal homology in their NH2-terminal region. Nurr1 is an atypical member of the NR superfamily, which are primarily ligand-activated receptors, which regulate gene expression via recognition of specific DNA-binding sequences. Nurr1 is important for dopaminergic neuron function via regulation of tyrosine hydoxylase expression. Preliminary reports suggest a role for Nurr1 in rheumatoid arthritis and cancer through modulation of apoptosis[2].
[1] BR De Miranda et al. The Nurr1 Activator 1,1-Bis(3'-Indolyl)-1-(p-Chlorophenyl)Methane Blocks Inflammatory Gene Expression in BV-2 Microglial Cells by Inhibiting Nuclear Factor κB. Mol Pharmacol. 2015 Jun;87(6):1021-34.
[2] T. Inamoto et al.1,1-Bis(3'-indolyl)-1-(p-chlorophenyl)methane activates the orphan nuclear receptor Nurr1 and inhibits bladder cancer growth. Mol Cancer Ther. 2008 Dec;7(12):3825-33.