Glucocorticoid (GR)

The third class of nuclear receptors (Nuclear, Class 3, Estrogen Receptor-like) includes estrogen and estrogen-related receptors (ER), as well as the 3-ketosteroid receptors (progesterone (PR), androgen (AR), gluco- and mineralocorticoid (GR and MR, respectively) receptors).
Corticosteroid receptors include mineralocorticoid (MR) and glucocorticoid (GR) receptors. They play a crucial role in the regulation of a variety of physiological processes, including reproduction, metabolism, salt balance, inflammation, and immunity. Cortisol is the principal glucocorticoid that induces the transcriptional activities of both the GR and MR, whereas the mineralocorticoid aldosterone also activates only MR, but not GR[1].

[1] Dissecting mineralocorticoid receptor structure and function. F.M. Rogerson, F.E. Brennan, P.J. Fuller. J Steroid Biochem. Mol. Biol. 2003, 85, 389-396.

16 Item(s)

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Axon ID Name Description From price
2239 (+)-ZK 216348 Selective nonsteroidal glucocorticoid receptor (GR) agonist €125.00
3882 Beclomethasone dipropionate Glucocorticoid €50.00
1426 Ciclesonide Glucocorticoid €65.00
4022 Deflazacort Glucocorticoid prodrug €80.00
3502 Desonide Corticosteroid €50.00
3258 Dexamethasone Glucocorticoid agonist €50.00
3345 Dexamethasone palmitate Prodrug of Dexamethasone; Glucocorticoid agonist €70.00
1427 Diflorasone Diacetate Corticosteroid €95.00
1428 Difluprednate Corticosteroid €75.00
1169 Flumethasone Selective and potent glucocorticoid receptor agonist €60.00
2247 Flumethasone pivalate Topical glucocorticoid receptor agonist €60.00
1429 Flunisolide Corticosteroid €95.00
1172 Fluticasone furoate Glucocorticoid agonist; MRP4 inhibitor €115.00
1404 Fluticasone propionate Glucocorticoid agonist €75.00
2066 Methylprednisolone Synthetic glucocorticoid drug; anti-inflammatory €65.00
1558 RU 42698 Metabolite of Mifepristone (Axon 1502) €125.00

16 Item(s)

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