Estrogen (ER)

The third class of nuclear receptors (Nuclear, Class 3, Estrogen Receptor-like) includes estrogen and estrogen-related receptors (ER), as well as the 3-ketosteroid receptors (progesterone (PR), androgen (AR), gluco- and mineralocorticoid (GR and MR, respectively) receptors). 
Estrogen is a key regulator of growth, differentiation and function in a broad range of target tissues, including the male and female reproductive tracts, mammary gland, bone, brain and the cardiovascular system. The biological effects of estrogen are mediated through estrogen receptors α and β (ERα, β). The classical mechanism of activation of ERs depends on ligand binding to the receptors, after which the receptors dimerize and bind to estrogen response elements (EREs) located in the promoters of estrogen-responsive genes. ERs may also regulate gene expression in the absence of DNA-binding by modulating the activities of other transcription factors via protein-protein interactions on DNA. This mechanism is referred to as cross-talk and is common for several nuclear receptors[1].  As the name implies, the family of estrogen receptor-related receptors (ERRs) is a subfamily of the orphan nuclear receptors, which is closely related to the estrogen receptor (ER) family, and comprises three subtypes (ERRα-γ). Sequence analyses comparing all the class 3 NRs have shown that both ERs and ERRs together form the same branch of class 3, which recognizes a specific hormone response element (HRE), whereas the other four steroid receptors (PR, AR, GR, and MR) recognize a different, yet specific HRE, thereby forming another branch[2].

[1] Estrogen receptor-dependent activation of AP-1 via non-genomic signaling. L. Björnström, M. Sjöberg. Nuclear Receptor 2004, 2, 3.
[2] The Orphan Nuclear Receptors, Estrogen Receptor-related Receptors: their Role as New Biomarkers in Gynecological Cancer. P. Sun, L. Wei, C. Denkert, W. Lichtenegger, J. Sehouli. Anticancer Res. 2006, 26 (2C), 1699-1706.

21 Item(s)

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Axon ID Name Description From price
3704 (S)-ErSO Inactive enantiomer of ErSO €180.00
4093 (Z)-4-Hydroxytamoxifen The more active metabolite of Tamoxifen (SERM; Axon 3252) €110.00
2221 (Z)-Endoxifen The more active (Z)-isomer of Endoxifen (SERM; Axon 2190) €150.00
2051 Bazedoxifene acetate Selective estrogen receptor modulator (SERM) €80.00
1748 Bazedoxifene hydrochloride Selective estrogen receptor modulator (SERM) €70.00
2790 BHPI ER-α antagonist €125.00
3650 Clomiphene citrate Selective estrogen receptor modulator (SERM) €50.00
3322 Dehydroepiandrosterone Endogenous steroid hormone precursor €60.00
3320 Diethylstilbestrol Estrogen receptor agonist €50.00
1232 DPN Estrogen (ER-β) agonist €70.00
4095 Elacestrant dihydrochloride Orally bioavailable selective estrogen receptor degrader (SERD) €220.00
2190 Endoxifen Selective estrogen receptor modulator (SERM) €125.00
2707 Endoxifen hydrochloride Selective estrogen receptor modulator (SERM) €130.00
1898 ERB 041 Selective estrogen receptor β (ERβ) agonist €95.00
3594 ErSO Orally bioavailable a-UPR activator €180.00
1926 Estetrol Estrogen receptor agonist, (four- to five-fold preference for the Erα) €130.00
1231 PPT ER-α agonist €95.00
3250 Raloxifene Selective estrogen receptor modulator (SERM) €50.00
3252 Tamoxifen Selective estrogen receptor modulator (SERM) €50.00
2697 WAY-200070 Brain penetrant ERβ-selective agonist €105.00
2652 ZB716 Steroidal, orally bioavailable SERD €130.00

21 Item(s)

per page
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