Retinoic Acid (RAR)

Retinoic Acid receptors (Nuclear class 1B, RARs, α, β, γ) are nuclear receptors related to the steroid and thyroid hormone receptors, a family of proteins that function as ligand-dependent transcription factors. The RARs show spatially restricted distribution patterns during embryogenesis, which have led to speculation on a variety of roles for retinoic acid (RA) in developmental processes. These receptors are retained in the nucleus regardless of the ligand binding status and in addition bind as hetero-dimers (usually with RXR) to DNA. RAR/RXR heterodimers regulate the transcriptional activation of primary RA target genes through binding to DNA-response elements termed RA response elements (RAREs)[1].

Retinoic acid receptors listed: RAR, RXR

[1] Retinoids, Retinoic Acid Receptors, and Cancer. X.H. Tang, L.J. Gudas. Annu. Rev. Pathol. Mech. Dis. 2011, 6, 345-364

4 Item(s)

per page
Axon ID Name Description From price
2902 QX77 Chaperone-mediated autophagy (CMA) activator €120.00
2637 LY 2955303 dihydrochloride Potent and selective RARγ antagonist for the treatment of osteoarthritis pain €145.00
1242 LE 135 RAR antagonist €120.00
2679 AR7 RARα antagonist that stimulates chaperone-mediated autophagy €90.00

4 Item(s)

per page
Please wait...