Retinoic Acid (RAR)

Retinoic Acid receptors (Nuclear class 1B, RARs, α, β, γ) are nuclear receptors related to the steroid and thyroid hormone receptors, a family of proteins that function as ligand-dependent transcription factors. The RARs show spatially restricted distribution patterns during embryogenesis, which have led to speculation on a variety of roles for retinoic acid (RA) in developmental processes. These receptors are retained in the nucleus regardless of the ligand binding status and in addition bind as hetero-dimers (usually with RXR) to DNA. RAR/RXR heterodimers regulate the transcriptional activation of primary RA target genes through binding to DNA-response elements termed RA response elements (RAREs)[1].

Retinoic acid receptors listed: RAR, RXR

[1] Retinoids, Retinoic Acid Receptors, and Cancer. X.H. Tang, L.J. Gudas. Annu. Rev. Pathol. Mech. Dis. 2011, 6, 345-364

9 Item(s)

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Axon ID Name Description From price
2948 AM 580 RAR-α agonist €95.00
2679 AR7 RARα antagonist that stimulates chaperone-mediated autophagy €90.00
1194 BMS 189961 RAR-γ agonist €145.00
1173 BMS 270394 RAR-γ agonist €165.00
1241 CH 55 RAR agonist €90.00
1242 LE 135 RAR antagonist €120.00
2637 LY 2955303 dihydrochloride Potent and selective RARγ antagonist for the treatment of osteoarthritis pain €145.00
2902 QX77 Chaperone-mediated autophagy (CMA) activator €120.00
3321 Retinoic acid RAR ligand €50.00

9 Item(s)

per page
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