A second member of the family of nuclear receptors (Nuclear class 1C, Thyroid Hormone Receptor-like) consists of peroxisome proliferator-activated receptors (PPAR, α, β, γ, and δ). They play essential roles in the regulation of cellular differentiation, development, and metabolism (carbohydrate, lipid, protein), and tumorigenesis of higher organisms. The clinical importance of PPARs originates with fibrates and thiazolidinediones (TZDs), which respectively act on PPAR-α and PPAR-γ. They are used to ameliorate hyperlipidemia and hyperglycemia in subjects with type 2 diabetes mellitus. More recently, proof was found that PPARs also contribute to the regulation of certain physiological activities of the prostacyclin (PGI2) system in cardiovascular tissues[1].

[1] Peroxisome Proliferator-Activated Receptors (PPARS): A Target with a Broad Therapeutic Potential for Human Diseases: An Overview. M.P. Singh, D. Pathak, G.K. Sharma, C.S. Sharma. Pharmacologyonline 2011, 2, 58-89.

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Axon ID Name Description From price
2443 Rosiglitazone PPARγ agonist; antidiabetic drug and stem cell differentiator €95.00
3255 Pioglitazone hydrochloride PPARγ agonist; antidiabetic drug €50.00
2533 Hydroxypioglitazone Active metabolite of Pioglitazone (M-IV), a PPARγ agonist €180.00
1950 CDDO A potent multifunctional anti-tumor agent. PPAR-γ agonist €80.00
3809 BAY-4931 Potent covalent PPARγ inverse agonist €120.00
3904 BAY-0069 Potent covalent PPARγ inverse agonist €90.00

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