PPAR
A second member of the family of nuclear receptors (Nuclear class 1C, Thyroid Hormone Receptor-like) consists of peroxisome proliferator-activated receptors (PPAR, α, β, γ, and δ). They play essential roles in the regulation of cellular differentiation, development, and metabolism (carbohydrate, lipid, protein), and tumorigenesis of higher organisms. The clinical importance of PPARs originates with fibrates and thiazolidinediones (TZDs), which respectively act on PPAR-α and PPAR-γ. They are used to ameliorate hyperlipidemia and hyperglycemia in subjects with type 2 diabetes mellitus. More recently, proof was found that PPARs also contribute to the regulation of certain physiological activities of the prostacyclin (PGI2) system in cardiovascular tissues[1].
[1] Peroxisome Proliferator-Activated Receptors (PPARS): A Target with a Broad Therapeutic Potential for Human Diseases: An Overview. M.P. Singh, D. Pathak, G.K. Sharma, C.S. Sharma. Pharmacologyonline 2011, 2, 58-89.
| Axon ID | Name | Description | From price | |
|---|---|---|---|---|
| 1227 | WY 14643 | PPARα agonist | €50.00 | |
| 3999 | Saroglitazar magnesium | Potent dual PPARα/γ agonist | €160.00 | |
| 2443 | Rosiglitazone | PPARγ agonist; antidiabetic drug and stem cell differentiator | €95.00 | |
| 3255 | Pioglitazone hydrochloride | PPARγ agonist; antidiabetic drug | €50.00 | |
| 2402 | MHY 908 | Dual PPARα/γ agonist, and potent inhibitor of mushroom tyrosinase | €95.00 | |
| 2814 | MHY 553 | PPARα agonist | €95.00 | |
| 1567 | KRP 297 | PPARα agonist; PPARγ agonist | €110.00 | |
| 2019 | INT131 | Selective PPARγ modulator (partial agonist) | €90.00 | |
| 2533 | Hydroxypioglitazone | Active metabolite of Pioglitazone (M-IV), a PPARγ agonist | €180.00 | |
| 1237 | GW 7647 | PPARα agonist | €95.00 | |
| 1628 | GSK 3787 | PPARδ antagonist | €90.00 | |
| 2727 | Elafibranor | Dual PPARα/δ agonist | €90.00 | |
| 2114 | CP 775146 | Potent and selective PPARα agonist | €85.00 | |
| 1950 | CDDO | A potent multifunctional anti-tumor agent. PPAR-γ agonist | €80.00 | |
| 3809 | BAY-4931 | Potent covalent PPARγ inverse agonist | €120.00 | |
| 3904 | BAY-0069 | Potent covalent PPARγ inverse agonist | €90.00 | |