CAR
Signalling via the constitutive androstane receptor (CAR;NR1I3) and pregnane X receptor (PXR;NR1I2) are major mechanisms for cellular response to exposure to xenobiotics and endogenous molecules[1]. CAR plays an important role orchestrating the metabolism and detoxification of potentially toxic chemicals, by upregulating genes that are involved in the clearance of both xenobiotics and endobiotics. Although CAR-mediated metabolism of drugs (e.g., acetaminophen) can lead to the production of toxic metabolites, induction of CAR regulated genes has emerged as a therapeutic strategy for the treatment of various diseases[2].