CAR

Signalling via the constitutive androstane receptor (CAR;NR1I3) and pregnane X receptor (PXR;NR1I2) are major mechanisms for cellular response to exposure to xenobiotics and endogenous molecules[1]. CAR plays an important role orchestrating the metabolism and detoxification of potentially toxic chemicals, by upregulating genes that are involved in the clearance of both xenobiotics and endobiotics. Although CAR-mediated metabolism of drugs (e.g., acetaminophen) can lead to the production of toxic metabolites, induction of CAR regulated genes has emerged as a therapeutic strategy for the treatment of various diseases[2].


[1] P Torres-Vergara et al. The constitutive androstane receptor and pregnane X receptor in the brain. Br J Pharmacol. 2020 Jun;177(12):2666-2682.
[2] D Liang et al. DL5050, a Selective Agonist for the Human Constitutive Androstane Receptor. ACS Med Chem Lett. 2019 Jun 12;10(7):1039-1044.

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Axon ID Name Description From price
3021 DL5050 Potent and highly selective hCAR agonist €140.00
3411 TCPOBOP CAR agonist €70.00

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