Peptide

Peptide receptors, in general, are members of the large family of G-protein coupled receptors (GPCRs). Their endogenous ligands are neuropeptides and proteins of various kinds, such as chemokine (subfamily A1), vasopressin (subfamily A6), neurokinin (subfamily A9), and thrombin (subfamily A15). The diversity of endogenous ligands implies the wide range of biological processes they are involved in: include learning, memory, response to stress, pain, addiction, feeding behavior, sexual behavior, reproduction, the immune response, thermal control, kidney function, cardiovascular function (including blood pressure and heart rate) and many others[1]. The discovery that peptide receptors (somatostatin (subfamily A4) in particular) are over-expressed in most human neuroendocrine tumors has focused the recent interest in peptide receptors as potential targets for the treatment of cancers[2].


[1] Designing peptide receptor agonists and antagonists. V.J. Hruby. Nature Reviews Drug Discovery 2002, 1, 847-858.
[2] Neuropeptide receptors in health and disease: the molecular basis for in vivo imaging. Reubi J.C.  J. Nucl. Med. 1995, 36,1825–1835.

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Axon ID Name Description From price
1501 PD 0220245 IL-8 antagonist €120.00
1276 PD 123319 ditrifluoroacetate AT2 antagonist €95.00
2055 Q94 hydrochloride Negative allosteric modulator of PAR1 (Gαq linkage) €80.00
1559 SB 265610 CXCR2 antagonist €95.00
2593 SB 332235 Nonpeptide CXCR2 antagonist exhibiting significant anti-inflammatory effects €105.00
2095 SB 334867 First selective orexin 1 (OX1) antagonist €90.00
2192 SB 674042 Nonpeptide OX1 selective antagonist with >100 fold selectivity over the OX2 receptor. €99.00
1755 SCH 530348 PAR1 antagonist €135.00
1275 SCH 79797 dihydrochloride PAR1 antagonist €120.00
1255 SR 142948 Neurotensin antagonist €125.00
1245 SR 27897 CCK1 antagonist €120.00
1164 SR 48692 Neurotensin 1 antagonist €70.00
1256 SR 49059 Vasopressin (V1A) antagonist €125.00
1114 SSR 149415 Vasopressin (V1B) antagonist €120.00
1270 T 98475 GnRH or LHRH antagonist Inquire

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