Peptide

Peptide receptors, in general, are members of the large family of G-protein coupled receptors (GPCRs). Their endogenous ligands are neuropeptides and proteins of various kinds, such as chemokine (subfamily A1), vasopressin (subfamily A6), neurokinin (subfamily A9), and thrombin (subfamily A15). The diversity of endogenous ligands implies the wide range of biological processes they are involved in: include learning, memory, response to stress, pain, addiction, feeding behavior, sexual behavior, reproduction, the immune response, thermal control, kidney function, cardiovascular function (including blood pressure and heart rate) and many others[1]. The discovery that peptide receptors (somatostatin (subfamily A4) in particular) are over-expressed in most human neuroendocrine tumors has focused the recent interest in peptide receptors as potential targets for the treatment of cancers[2].


[1] Designing peptide receptor agonists and antagonists. V.J. Hruby. Nature Reviews Drug Discovery 2002, 1, 847-858.
[2] Neuropeptide receptors in health and disease: the molecular basis for in vivo imaging. Reubi J.C.  J. Nucl. Med. 1995, 36,1825–1835.

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Axon ID Name Description From price
1569 GW 803430 MCH1 antagonist €85.00
3043 I-191 Potent PAR2 antagonist €175.00
3071 LIT-001 Potent and specific oxytocin receptor agonist €145.00
2921 LIT-927 Selective, locally and orally active CXCL12 neutraligand €95.00
3102 Losartan Non-peptide, potent and orally active angiotensin II receptor antagonist €60.00
1969 M 24 First non-peptide selective AT2 receptor agonist Inquire
1376 MK 677 Growth hormone secretagogue (GHS) agonist €85.00
2321 ML 154 Competitive, selective, and brain penetrant NPS receptor antagonist €120.00
1928 ML 161 Allosteric inhibitor of PAR1 €90.00
2870 ML 221 Apelin receptor (APJ) antagonist €95.00
2632 ML314 Brain penetrant nonpeptidic β-Arrestin biased agonist of NTR1 €95.00
2499 Netupitant Selective NK1 antagonist; Prevents chemotherapy-induced nausea and vomiting €140.00
3105 Olmesartan Potent and selective AT1 antagonist €80.00
1618 Orvepitant maleate NK1 antagonist €115.00
1533 Osanetant NK3 antagonist €150.00

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