Peptide

Peptide receptors, in general, are members of the large family of G-protein coupled receptors (GPCRs). Their endogenous ligands are neuropeptides and proteins of various kinds, such as chemokine (subfamily A1), vasopressin (subfamily A6), neurokinin (subfamily A9), and thrombin (subfamily A15). The diversity of endogenous ligands implies the wide range of biological processes they are involved in: include learning, memory, response to stress, pain, addiction, feeding behavior, sexual behavior, reproduction, the immune response, thermal control, kidney function, cardiovascular function (including blood pressure and heart rate) and many others[1]. The discovery that peptide receptors (somatostatin (subfamily A4) in particular) are over-expressed in most human neuroendocrine tumors has focused the recent interest in peptide receptors as potential targets for the treatment of cancers[2].


[1] Designing peptide receptor agonists and antagonists. V.J. Hruby. Nature Reviews Drug Discovery 2002, 1, 847-858.
[2] Neuropeptide receptors in health and disease: the molecular basis for in vivo imaging. Reubi J.C.  J. Nucl. Med. 1995, 36,1825–1835.

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Axon ID Name Description From price
1901 Casopitant mesylate NK1 antagonist €125.00
2665 Cenicriviroc Oral CCR5-antagonist for treatment of HIV infection €145.00
2147 CpdD hydrochloride Ghrelin receptor (GhrR aka GHSR-1a) antagonist €135.00
1800 CXCR3 Antagonist 6c CXCR3 antagonist €135.00
2895 D3-βArr Positive allosteric modulator (PAM) of TSH receptor €105.00
1975 Dilept Neurotensin and dopamine receptor antagonist €90.00
2030 E 5555 hydrobromide Potent and orally active PAR1 antagonist €115.00
2012 EMPA Orexin type 2 (OX2) receptor antagonist €135.00
2146 Fedovapagon Selective vasopressin V2 receptor agonist €120.00
1607 FK 960 Somatostatin agonist €95.00
3198 FK962 Enhancer of somatostatin release €95.00
1622 GB 83 PAR2 antagonist €110.00
1132 GLP-1 antagonist GLP-1 Receptor Antagonist €150.00
1907 GLP-1R agonist DMB GLP-1 Receptor (GLP1R) Agonist €99.00
1119 GR 159897 NK2 antagonist €105.00

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