Peptide

Peptide receptors, in general, are members of the large family of G-protein coupled receptors (GPCRs). Their endogenous ligands are neuropeptides and proteins of various kinds, such as chemokine (subfamily A1), vasopressin (subfamily A6), neurokinin (subfamily A9), and thrombin (subfamily A15). The diversity of endogenous ligands implies the wide range of biological processes they are involved in: include learning, memory, response to stress, pain, addiction, feeding behavior, sexual behavior, reproduction, the immune response, thermal control, kidney function, cardiovascular function (including blood pressure and heart rate) and many others[1]. The discovery that peptide receptors (somatostatin (subfamily A4) in particular) are over-expressed in most human neuroendocrine tumors has focused the recent interest in peptide receptors as potential targets for the treatment of cancers[2].


[1] Designing peptide receptor agonists and antagonists. V.J. Hruby. Nature Reviews Drug Discovery 2002, 1, 847-858.
[2] Neuropeptide receptors in health and disease: the molecular basis for in vivo imaging. Reubi J.C.  J. Nucl. Med. 1995, 36,1825–1835.

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Axon ID Name Description From price
1179 A1B1 hydrochloride CCR1 antagonist €125.00
1738 AMD 3100 CXCR4 antagonist €85.00
1930 AMD 3465 hexahydrobromide Potent and selective CXCR4 antagonist €85.00
2842 AZD 2098 Potent, selective and bioavailable CCR4 receptor antagonist €125.00
2255 AZD 8797 Potent and selective antagonist of the Fractalkine receptor (FKN or CX3CR1) €120.00
2082 BX 471 Selective CCR1 receptor antagonist €105.00
2665 Cenicriviroc Oral CCR5-antagonist for treatment of HIV infection €145.00
1800 CXCR3 Antagonist 6c CXCR3 antagonist €135.00
2921 LIT-927 Selective, locally and orally active CXCL12 neutraligand €95.00
1559 SB 265610 CXCR2 antagonist €95.00
2593 SB 332235 Nonpeptide CXCR2 antagonist exhibiting significant anti-inflammatory effects €105.00
2993 UNBS5162 Pan-antagonist of CXCL chemokine expression €95.00
2685 Vercirnon CCR9 antagonist €135.00
1620 WZ 811 CXCR4 antagonist €80.00
2636 YJC-10592 CCR2 antagonist €145.00

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