Peptide receptors, in general, are members of the large family of G-protein coupled receptors (GPCRs). Their endogenous ligands are neuropeptides and proteins of various kinds, such as chemokine (subfamily A1), vasopressin (subfamily A6), neurokinin (subfamily A9), and thrombin (subfamily A15). The diversity of endogenous ligands implies the wide range of biological processes they are involved in: include learning, memory, response to stress, pain, addiction, feeding behavior, sexual behavior, reproduction, the immune response, thermal control, kidney function, cardiovascular function (including blood pressure and heart rate) and many others[1]. The discovery that peptide receptors (somatostatin (subfamily A4) in particular) are over-expressed in most human neuroendocrine tumors has focused the recent interest in peptide receptors as potential targets for the treatment of cancers[2].

[1] Designing peptide receptor agonists and antagonists. V.J. Hruby. Nature Reviews Drug Discovery 2002, 1, 847-858.
[2] Neuropeptide receptors in health and disease: the molecular basis for in vivo imaging. Reubi J.C.  J. Nucl. Med. 1995, 36,1825–1835.

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3386 AVE0991 Selective and orally active Mas receptor agonist €150.00
3363 Azilsartan Potent AT1 antagonist €60.00
3104 Candesartan cilexetil Potent and highly specific AT2 receptor antagonist €50.00
3102 Losartan Non-peptide, potent and orally active angiotensin II receptor antagonist €60.00
1969 M 24 First non-peptide selective AT2 receptor agonist Inquire
3105 Olmesartan Potent and selective AT1 antagonist €80.00
1276 PD 123319 ditrifluoroacetate AT2 antagonist €95.00
3103 Telmisartan Non-peptide, highly potent and selective AT1 receptor antagonist €60.00
3106 Valsartan Potent, highly selective, and orally active AT1 antagonist €76.00

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