Peptide

Peptide receptors, in general, are members of the large family of G-protein coupled receptors (GPCRs). Their endogenous ligands are neuropeptides and proteins of various kinds, such as chemokine (subfamily A1), vasopressin (subfamily A6), neurokinin (subfamily A9), and thrombin (subfamily A15). The diversity of endogenous ligands implies the wide range of biological processes they are involved in: include learning, memory, response to stress, pain, addiction, feeding behavior, sexual behavior, reproduction, the immune response, thermal control, kidney function, cardiovascular function (including blood pressure and heart rate) and many others[1]. The discovery that peptide receptors (somatostatin (subfamily A4) in particular) are over-expressed in most human neuroendocrine tumors has focused the recent interest in peptide receptors as potential targets for the treatment of cancers[2].


[1] Designing peptide receptor agonists and antagonists. V.J. Hruby. Nature Reviews Drug Discovery 2002, 1, 847-858.
[2] Neuropeptide receptors in health and disease: the molecular basis for in vivo imaging. Reubi J.C.  J. Nucl. Med. 1995, 36,1825–1835.

6 Item(s)

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Axon ID Name Description From price
1486 Aprepitant Substance P antagonist (SPA); NK1 inhibitor €80.00
1901 Casopitant mesylate NK1 antagonist €125.00
1119 GR 159897 NK2 antagonist €105.00
2499 Netupitant Selective NK1 antagonist; Prevents chemotherapy-induced nausea and vomiting €140.00
1618 Orvepitant maleate NK1 antagonist €115.00
1533 Osanetant NK3 antagonist €150.00

6 Item(s)

per page
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