Peptide

Peptide receptors, in general, are members of the large family of G-protein coupled receptors (GPCRs). Their endogenous ligands are neuropeptides and proteins of various kinds, such as chemokine (subfamily A1), vasopressin (subfamily A6), neurokinin (subfamily A9), and thrombin (subfamily A15). The diversity of endogenous ligands implies the wide range of biological processes they are involved in: include learning, memory, response to stress, pain, addiction, feeding behavior, sexual behavior, reproduction, the immune response, thermal control, kidney function, cardiovascular function (including blood pressure and heart rate) and many others[1]. The discovery that peptide receptors (somatostatin (subfamily A4) in particular) are over-expressed in most human neuroendocrine tumors has focused the recent interest in peptide receptors as potential targets for the treatment of cancers[2].


[1] Designing peptide receptor agonists and antagonists. V.J. Hruby. Nature Reviews Drug Discovery 2002, 1, 847-858.
[2] Neuropeptide receptors in health and disease: the molecular basis for in vivo imaging. Reubi J.C.  J. Nucl. Med. 1995, 36,1825–1835.

Items 1 to 15 of 71 total

per page
Page:
  1. 1
  2. 2
  3. 3
  4. 4
  5. 5
Axon ID Name Description From price
2861 ZK 756326 dihydrochloride CCR8 agonist €90.00
2636 YJC-10592 CCR2 antagonist €145.00
1620 WZ 811 CXCR4 antagonist €80.00
2711 WAY-267464 dihydrochloride Oxytocin receptor agonist €85.00
2685 Vercirnon CCR9 antagonist €135.00
1867 Vasopressin antagonist 1867 Orally available and selective V1b receptor antagonist €125.00
3106 Valsartan Potent, highly selective, and orally active AT1 antagonist €76.00
2993 UNBS5162 Pan-antagonist of CXCL chemokine expression €95.00
1591 Tolvaptan Vasopressin (V2) antagonist €105.00
3103 Telmisartan Non-peptide, highly potent and selective AT1 receptor antagonist €60.00
2744 TCS1102 Dual orexin (OX1/2) receptor antagonist €90.00
1270 T 98475 GnRH or LHRH antagonist Inquire
1114 SSR 149415 Vasopressin (V1B) antagonist €120.00
1256 SR 49059 Vasopressin (V1A) antagonist €125.00
1164 SR 48692 Neurotensin 1 antagonist €70.00

Items 1 to 15 of 71 total

per page
Page:
  1. 1
  2. 2
  3. 3
  4. 4
  5. 5
Please wait...