Peptide receptors, in general, are members of the large family of G-protein coupled receptors (GPCRs). Their endogenous ligands are neuropeptides and proteins of various kinds, such as chemokine (subfamily A1), vasopressin (subfamily A6), neurokinin (subfamily A9), and thrombin (subfamily A15). The diversity of endogenous ligands implies the wide range of biological processes they are involved in: include learning, memory, response to stress, pain, addiction, feeding behavior, sexual behavior, reproduction, the immune response, thermal control, kidney function, cardiovascular function (including blood pressure and heart rate) and many others[1]. The discovery that peptide receptors (somatostatin (subfamily A4) in particular) are over-expressed in most human neuroendocrine tumors has focused the recent interest in peptide receptors as potential targets for the treatment of cancers[2].

[1] Designing peptide receptor agonists and antagonists. V.J. Hruby. Nature Reviews Drug Discovery 2002, 1, 847-858.
[2] Neuropeptide receptors in health and disease: the molecular basis for in vivo imaging. Reubi J.C.  J. Nucl. Med. 1995, 36,1825–1835.

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2898 AC 264613 Potent, selective, and metabolically stable PAR2 agonist €95.00
3386 AVE0991 Selective and orally active Mas receptor agonist €150.00
2259 BETP Positive allosteric modulator (PAM) at the GLP-1 receptor €105.00
2146 Fedovapagon Selective vasopressin V2 receptor agonist €120.00
1607 FK 960 Somatostatin agonist €95.00
1907 GLP-1R agonist DMB GLP-1 Receptor (GLP1R) Agonist €99.00
3071 LIT-001 Potent and specific oxytocin receptor agonist €145.00
1969 M 24 First non-peptide selective AT2 receptor agonist Inquire
1376 MK 677 Growth hormone secretagogue (GHS) agonist €85.00
2632 ML314 Brain penetrant nonpeptidic β-Arrestin biased agonist of NTR1 €95.00
3103 Telmisartan Non-peptide, highly potent and selective AT1 receptor antagonist €60.00
2711 WAY-267464 dihydrochloride Oxytocin receptor agonist €85.00
2861 ZK 756326 dihydrochloride CCR8 agonist €90.00

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