Lysophosphatidic acid (LPA) is a natural bioactive lipid that acts through six different G protein-coupled receptors (LPA1-6) with pleiotropic activities on multiple cell types. LPA is known for a plethora of actions in the normal function of our organism as well as in the pathogenesis of many diseases[1]. It participates in the biosynthesis, catabolism and transport of phospholipids in the organism, and in the continuous turnover of membranous organelles, such as the plasma membrane, endoplasmic reticula or Golgi apparatus. Interestingly, LPA also plays another very important role as a mediator in cell communication in autocrine, paracrine and endocrine ways.
LPA actions are mediated mainly through a family of GPCRs (LPA1-7), but it is also known to modulate transcription through nuclear receptors, such as the ligand-activated peroxisome proliferator-activated receptor γ (PPARγ)[2]. The LPA1 receptor has been detected, in the brain, heart, intestine, ovaries, testis, prostate, thymus and pancreas, among others, and mediates in a wide variety of cellular responses including cell proliferation, survival, cell shape changes and cytoskeletal rearrangements, migration, rearrangements in cell-cell contacts, among many others.

Lysophospholipid receptor subtypes listed: LPA1, S1PR1, S1PR2, S1PR3

[1] M.David et al. Lysophosphatidic acid receptor type 1 (LPA1) plays a functional role in osteoclast differentiation and bone resorption activity. J. Biol. Chem. 2014, 289, 6551-6564.
[2] A. Hernández-Méndez, et al. Lysophosphatidic acid LPA1-3 receptors: signaling, regulation and in silico analysis of their putative phosphorylation sites. Receptors Clin. Invest. 2014, 1, e193.

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Axon ID Name Description From price
2367 AM 095 (parent compound) Novel potent and selective LPA1 antagonist €125.00
3609 AS2717638 Highly potent, selective, orally active, and brain-penetrant LPA receptor 5 antagonist €180.00

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