Calcium Sensing

The calcium-sensing receptor (CaSR), a receptor which senses extracellular levels of calcium ion, is also classified as a member of the family of class C GPCRs. The release of  parathyroid hormone (PTH) is inhibited in response to elevations in plasma calcium concentrations and activation of the calcium receptor by activating the phospholipase C (PLC) pathway, presumably through a Gqα type of G protein[1].


[1] Calcium-sensing receptor and calcimimetic agents. J.W. Coburn, L. Elangovan, W.G. Goodman, J.M. Frazaõ. Kidney Int. Suppl. 1999, 73, S52-58.

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2942 DJ-V-159 Selective GPRC6A agonist €95.00

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