VEGF is one of the key regulators of angiogenesis, vasculogenesis, and developmental hematopoiesis. It is a mitogen and survival factor for vascular endothelial cells while also promoting vascular endothelial cell and monocyte motility[1]. Binding of growth factors to the ectodomain of their transmembrane receptors leads to receptor dimerization, protein kinase activation, trans-autophosphorylation, and initiation of signaling pathways. The VEGF family of receptors (RTK class IV, VEGF receptor family) consists of three protein–tyrosine kinases (VEGFR1, VEGFR2, and VEGFR3) and two non-protein kinase co-receptors (neuropilin-1 and 2)[2]. Targeting VEGF receptors proved to be a successful therapeutic approach for disorders with non-physiologic angiogenesis including age-related macular degeneration of the eye, diabetic retinopathy, rheumatoid arthritis, tumor growth and metastasis1.

[1] Vascular endothelial growth factor (VEGF) signaling during tumor progression. A comprehensive review of the discovery of the VEGF family of ligands and receptors. R. Roskoski Jr. Crit. Rev. Oncol. Hematol. 2007, 62, 179–213.
[2] VEGF receptor protein–tyrosine kinases: Structure and regulation. Mini Review. R. Roskoski Jr. Biochem. Biophys. Res. Com. 2008, 375, 287–291.

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Axon ID Name Description From price
2849 Apatinib Inhibitor of VEGFR2 €120.00
1850 BMS 540215 Inhibitor of VEGFR (subtype 2 and 3 selective) €110.00
2837 BMS 605541 Potent, selective, orally active, and ATP-competitive VEGFR2 inhibitor €90.00
1864 Brivanib alaninate Prodrug of BMS 540215; Inhibitor of VEGF €90.00
1461 Cediranib VEGFR tyrosine kinase inhibitor €70.00
1662 CP 547632 VEGFR2 tyrosine kinase inhibitor €70.00
3165 Lenvatinib Multi-targeted receptor tyrosine kinase inhibitor €70.00
1963 LY 573636 Anti-tumor agent; causes growth arrest and apoptosis €80.00
3998 MGCD516 Orally bioavailable receptor tyrosine kinase (RTK) inhibitor Inquire
2865 NVP-ACC789 Inhibitor of VEGFR2 €90.00
3338 Taxifolin Inhibitor of VEGFR2 €50.00
1717 Tivozanib VEGFR1, 2, and 3 tyrosine kinase inhibitor €80.00
1637 Vatalanib VEGFR tyrosine kinase inhibitor €75.00
1978 ZM 323881 hydrochloride Inhibitor of VEGFR2 €105.00

14 Item(s)

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