VEGFR
VEGF is one of the key regulators of angiogenesis, vasculogenesis, and developmental hematopoiesis. It is a mitogen and survival factor for vascular endothelial cells while also promoting vascular endothelial cell and monocyte motility[1]. Binding of growth factors to the ectodomain of their transmembrane receptors leads to receptor dimerization, protein kinase activation, trans-autophosphorylation, and initiation of signaling pathways. The VEGF family of receptors (RTK class IV, VEGF receptor family) consists of three protein–tyrosine kinases (VEGFR1, VEGFR2, and VEGFR3) and two non-protein kinase co-receptors (neuropilin-1 and 2)[2]. Targeting VEGF receptors proved to be a successful therapeutic approach for disorders with non-physiologic angiogenesis including age-related macular degeneration of the eye, diabetic retinopathy, rheumatoid arthritis, tumor growth and metastasis1.
[1] Vascular endothelial growth factor (VEGF) signaling during tumor progression. A comprehensive review of the discovery of the VEGF family of ligands and receptors. R. Roskoski Jr. Crit. Rev. Oncol. Hematol. 2007, 62, 179–213.
[2] VEGF receptor protein–tyrosine kinases: Structure and regulation. Mini Review. R. Roskoski Jr. Biochem. Biophys. Res. Com. 2008, 375, 287–291.
| Axon ID | Name | Description | From price | |
|---|---|---|---|---|
| 2849 | Apatinib | Inhibitor of VEGFR2 | €120.00 | |
| 1850 | BMS 540215 | Inhibitor of VEGFR (subtype 2 and 3 selective) | €110.00 | |
| 2837 | BMS 605541 | Potent, selective, orally active, and ATP-competitive VEGFR2 inhibitor | €90.00 | |
| 1864 | Brivanib alaninate | Prodrug of BMS 540215; Inhibitor of VEGF | €90.00 | |
| 1461 | Cediranib | VEGFR tyrosine kinase inhibitor | €70.00 | |
| 1662 | CP 547632 | VEGFR2 tyrosine kinase inhibitor | €70.00 | |
| 3165 | Lenvatinib | Multi-targeted receptor tyrosine kinase inhibitor | €70.00 | |
| 1963 | LY 573636 | Anti-tumor agent; causes growth arrest and apoptosis | €80.00 | |
| 3998 | MGCD516 | Orally bioavailable receptor tyrosine kinase (RTK) inhibitor | Inquire | |
| 2865 | NVP-ACC789 | Inhibitor of VEGFR2 | €90.00 | |
| 3338 | Taxifolin | Inhibitor of VEGFR2 | €50.00 | |
| 1717 | Tivozanib | VEGFR1, 2, and 3 tyrosine kinase inhibitor | €80.00 | |
| 1637 | Vatalanib | VEGFR tyrosine kinase inhibitor | €75.00 | |
| 1978 | ZM 323881 hydrochloride | Inhibitor of VEGFR2 | €105.00 | |