MST1R
The MST1R (also known as RON) receptor tyrosine kinase (RTK) is a member of the c-Met family of RTKs that is expressed in epithelial cells and terminally-differentiated macrophages. MST1R is overexpressed in numerous solid tumors including breast, prostate, pancreas, and more with strong oncogenic function elicited through various signaling mechanisms[1].
[1] BG Hunt et al. MST1R (RON) expression is a novel prognostic biomarker for metastatic progression in breast cancer patients. Breast Cancer Res Treat. 2020 Jun;181(3):529-540.
| Axon ID | Name | Description | From price | |
|---|---|---|---|---|
| 2553 | LY 2801653 | Orally bioavailable multi-kinase inhibitor with potent activity against c-MET | €120.00 | |