The protein encoded by this gene is a member of the receptor tyrosine kinase subfamily (RTK class IX). Mer belongs to the TAM (Tyro3, Axl, and Mer) RTK family, whose members function as inhibitors of innate inflammatory responses in dendritic cells and are essential to the prevention of lupus-like autoimmunity. Additionally, the members of this family of RTKs have been implicated in the development and metastasis of many cancers, including hematological malignancies and solid tumors of the colon, brain and breast.[1] Although it is similar to other receptor tyrosine kinases, this protein represents a unique structure of the extracellular region that juxtaposes IgL and FNIII repeats. It transduces signals from the extracellular matrix into the cytoplasm by binding growth factors like vitamin K-dependent protein growth-arrest-specific gene 6. It is involved in the stimulation of cell proliferation and can also mediate cell aggregation by homophilic binding[2].

[1] Mer or Axl receptor tyrosine kinase inhibition promotes apoptosis, blocks growth and enhances chemosensitivity of human non-small cell lung cancer. R.M.A. Linger et al. Oncogene 2012, 1–12.
[2] Identification of Axl as a downstream effector of TGF-β1 during Langerhans cell differentiation and epidermal homeostasis. Bauer T, Zagórska A, Jurkin J, Yasmin N, Köffel R, Richter S, Gesslbauer B, Lemke G, Strobl H. J. Exp. Med. 2012, 209, 2033-2047

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Axon ID Name Description From price
2086 UNC569 Reversible and ATP-competitive inhibitor of Mer (RTK) €95.00
2346 UNC2250 Potent Mer kinase inhibitor with promising selectivity and PK properties. €80.00
3998 MGCD516 Orally bioavailable receptor tyrosine kinase (RTK) inhibitor Inquire
2553 LY 2801653 Orally bioavailable multi-kinase inhibitor with potent activity against c-MET €120.00

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