Stem cell factor (SCF, also called Steel factor or Kit ligand) is a dimeric molecule that exerts its biological functions by binding to and activating the receptor tyrosine kinase c-KIT or CD117 (RTK class III, PDGF receptor family). It is also classified as cytokine receptor. Activation of c-Kit leads to its autophosphorylation and initiation of signal transduction. Signaling proteins are recruited to activated c-Kit by certain interaction domains (e.g., SH2 and PTB) that specifically bind to phosphorylated tyrosine residues in the intracellular region of c-Kit. It is expressed by fibroblasts and endothelial cells throughout the body, and activation of c-Kit signaling has been found to mediate cell survival, migration, and proliferation depending on the cell type. Signaling from c-Kit is crucial for normal hematopoiesis, pigmentation, fertility, gut movement, and some aspects of the nervous system. Deregulated c-Kit kinase activity has been found in a number of pathological conditions, including cancer and allergy[1].

[1] J. Lennartsson et al. Stem cell factor receptor/c-Kit: from basic science to clinical implications. Physiol. Rev. 2012, 92, 1619-1649.

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1638 ABT 869 PDGFR, c-KIT and VEGFR tyrosine kinase inhibitor €85.00
1414 AG 013736 PDGFR,c-KIT and VEGFR tyrosine kinase inhibitor €65.00
1768 AMG 706 Multiple receptor tyrosine kinase inhibitor €105.00
1420 GW 786034 PDGFR, c-KIT and VEGFR tyrosine kinase inhibitor €70.00
2767 SU11652 Multi-targeted receptor tyrosine kinase inhibitor €145.00
1398 Sunitinib malate Multi-targeted receptor tyrosine kinase inhibitor €80.00

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