Cytokine
Cytokines and chemokines are both small proteins made by cells in the immune system. They are important in the production and growth of lymphocytes, and in regulating responses to infection or injury such as inflammation and wound healing. Cytokines are the general category of messenger molecules, while chemokines are a special type of cytokine that direct the migration (chemotaxis) of white blood cells to infected or damaged tissues. Unlike most other cytokines, chemokines regulate their action through interactions with seven-transmembrane, rhodopsin-like G protein-coupled receptors (GPCRs)[1]. Cytokines are secreted in the mammalian immune system, and used as messenger molecules to control the duration and strength of the immune response to foreign microorganisms. Many cytokines produced by T cells direct the immune response of various white blood cells (leukocytes) to a foreign microorganism in the body. Among the important varieties are the interleukin (IL) molecules and interferon alpha and beta. The ILs help regulate inflammation, fever, and wound healing, among other things, while the interferons block the replication of viruses[2],[3]. As part of the superfamily of cytokine receptors belongs to the large family of GPCR receptors (GPCR-A1 and A2), among which the CCR and CXC type chemokine receptors, Axon Ligands™ that interact with these receptors have thus been listed in the corresponding sections of the GPCR receptors as well. Additionally, the superfamily of cytokine receptors differentiates tumor necrosis factor (TNF) type receptors and interleukin (IL) type receptors, and a small sub-family of other cytokine receptors that do not fit into the previously lised subfamilies, based on either structure or function.
[1] M.J. Cameron, D.J. Kelvin. Cytokines, Chemokines and Their Receptors. Mdm. Curie Biosc. Dbase [Internet]. Landes Bioscience 2000. http://www.ncbi.nlm.nih.gov/books/NBK6294/
[2] L.C. Borish, J.W. Steinke. 2. Cytokines and chemokines. J. Allergy Clin. Immunol. 2003, 111, S460-75.
[3] C.A. Dinarello. Historical Review of Cytokines. Eur. J. Immunol. 2007, 37, S34-S45.
Axon ID | Name | Description | From price | |
---|---|---|---|---|
3189 | 4-CPPC | First potent, selective and reversible inhibitor of MIF-2 | €135.00 | |
1369 | Apilimod | Cytokine inhibitor; IL-12 and IL-23 inhibitor | €110.00 | |
2500 | Apilimod dimesylate | Cytokine inhibitor; IL-12 and IL-23 inhibitor | €110.00 | |
3428 | CSF1R inhibitor compound 22 | Potent, cellular active and orally bioavailable CSF1R inhibitor | €130.00 | |
2887 | DRI-C21045 | Inhibitor of the CD40-CD40L costimulatory protein-protein interaction | €125.00 | |
2800 | Ensemble Compound 159 | Cytokine inhibitor; IL-17A inhibitor | Inquire | |
2571 | GW 2580 | Orally bioavailable inhibitor of cFMS kinase and CSF1R | €75.00 | |
4237 | IL-4-inhibitor-1 | First IL-4 inhibitor | Recently added | €110.00 |
3949 | ISO-1 | MIF inhibitor | €120.00 | |
1793 | Lenalidomide | TNFα inhibitor. Immunomodulator. | €40.00 | |
2966 | NSC745887 | DcR3 inhibitor | €95.00 | |
2501 | Pexidartinib | Mutil-targeted RTK inhibitor of CSF1R, c-Kit, and FLT3 | €60.00 | |
3054 | PLX5622 | Potent, specific, orally bioavailable and brain-penetrant inhibitor of CSF1R | €80.00 | |
3166 | Pomalidomide | TNFα inhibitor. Immunomodulator. | €60.00 | |
2324 | SC 144 hydrochloride | The first-in-class small-molecule gp130 inhibitor | €130.00 | |
4084 | Sotuletinib | Potent, selective and brain-penetrant inhibitor of CSF1R | €120.00 | |
2143 | SPD 304 | Cell permeable inhibitor of TNFα | €145.00 | |
3324 | Thalidomide | TNFα inhibitor. Immunomodulator. | €50.00 |