Neurotransmitters

Intercellular communication in the central nervous system requires the precise control of the duration and the intensity of neurotransmitter action at the specific receptors. After they have been released at the synapse, neurotransmitters activate pre- and/or postsynaptic receptors. To terminate synaptic transmission, neurotransmitters can, in turn, be inactivated by either enzymatic degradation or active transport into neuronal and/or glial cells by neurotransmitter transporters[1]. Reuptake inhibitors of neurotransmitters have a direct effect on extracellular concentrations of neurotransmitters in the synapses, and therefore influence neurotransmission. Axon Medchem offers inhibitors for a wide range of (monoamine) reuptake inhibitors of high quality.


[1] Neurotransmitter Transporters in the Central Nervous System. J. Masson, C. Sagné, M. Hamon, S. El Mestikawy. Pharm. Rev. 1999, 51, 439-464.

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Axon ID Name Description From price
2260 LDN 212320 Activator of EAAT2 translation; neuroprotectant €90.00
1139 LY 393558 SSRI; 5-HT1B and 5-HT1D antagonist €125.00
2587 ML352 Potent and selective inhibitor of the presynaptic choline transporter CHT €105.00
2329 NS 19504 Potent activator of large-conductance Ca2+-activated potassium (BK) channels €90.00
1563 ORG 25935 GlyT-1 inhibitor €95.00
1452 Paroxetine hydrochloride SSRI €75.00
1123 Radafaxine hydrochloride NDRI €95.00
1240 Reboxetine mesylate Noradrenaline reuptake inhibitor (NARI) €105.00
1300 Sertraline hydrochloride SSRI; Antidepressant €85.00
1236 SKF 83566 hydrobromide D1 antagonist €70.00
1549 SSR 504734 GlyT-1 inhibitor €105.00
2427 TBOA ammonia salt, L- Very potent blocker of EAAT1–3 €135.00
2640 TFB-TBOA Very potent blocker of human excitatory amino acid transporters (EAAT1-2) €145.00
1727 Venlafaxine hydrochloride SNRI €65.00
2670 VU6001221 Choline transporter inhibitor €125.00

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