Neurotransmitters

Intercellular communication in the central nervous system requires the precise control of the duration and the intensity of neurotransmitter action at the specific receptors. After they have been released at the synapse, neurotransmitters activate pre- and/or postsynaptic receptors. To terminate synaptic transmission, neurotransmitters can, in turn, be inactivated by either enzymatic degradation or active transport into neuronal and/or glial cells by neurotransmitter transporters[1]. Reuptake inhibitors of neurotransmitters have a direct effect on extracellular concentrations of neurotransmitters in the synapses, and therefore influence neurotransmission. Axon Medchem offers inhibitors for a wide range of (monoamine) reuptake inhibitors of high quality.


[1] Neurotransmitter Transporters in the Central Nervous System. J. Masson, C. Sagné, M. Hamon, S. El Mestikawy. Pharm. Rev. 1999, 51, 439-464.

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Axon ID Name Description From price
1238 ALX 5407 hydrochloride GlyT-1 inhibitor €140.00
1333 Amoxapine Tricyclic antidepressant; Potent reuptake inhibitor of norepinephrine (NRI) €50.00
1297 Atomoxetine hydrochloride NRI inhibitor €95.00
1462 Azaphen Antidepressant €105.00
1257 BTS 54-505 5-HT uptake inhibitor €85.00
1451 Bupropion hydrochloride DRI and NRI; nicotinic acetylcholine receptor antagonist €85.00
3619 Chlorphentermine hydrochloride Serotonin transporter (SERT) substrate €95.00
1320 Citalopram hydrobromide SSRI; Antidepressant €75.00
1722 Deshydroxy Venlafaxine HCl Metabolite of Venlafaxine; SNRI €95.00
3555 Desvenlafaxine hydrochloride Metabolite of Venlafaxine; SNRI €70.00
1726 Dinorvenlafaxine Metabolite of Venlafaxine; SNRI €75.00
3315 Escitalopram oxalate SSRI; Antidepressant €50.00
1302 Fluoxetine hydrochloride SSRI €75.00
1556 Fluvoxamine maleate SSRI €50.00
1203 GBR 12783 dihydrochloride Dopamine uptake inhibitor €85.00
3355 IDT307 DAT/NET/SERT substrate; Fluorescent dye €90.00
2427 L-TBOA ammonia salt Very potent blocker of EAAT1–3 €135.00
2260 LDN 212320 Activator of EAAT2 translation; neuroprotectant €90.00
3128 Levomilnacipran hydrochloride SNRI €120.00
1139 LY 393558 SSRI; 5-HT1B and 5-HT1D antagonist €125.00
2587 ML352 Potent and selective inhibitor of the presynaptic choline transporter CHT €105.00
2329 NS 19504 Potent activator of large-conductance Ca2+-activated potassium (BK) channels €90.00
3578 O-Desmethylvenlafaxine Metabolite of Venlafaxine; SNRI €70.00
2116 O-Desmethylvenlafaxine succinate Metabolite of Venlafaxine; SNRI €90.00
1563 ORG 25935 GlyT-1 inhibitor €90.00
1452 Paroxetine hydrochloride SSRI €75.00
1720 R-(-)-O-Desmethylvenlafaxine Metabolite of Venlafaxine; SNRI €125.00
1123 Radafaxine hydrochloride NDRI €110.00
1240 Reboxetine mesylate Noradrenaline reuptake inhibitor (NARI) €120.00
1721 S-(+)-O-Desmethylvenlafaxine Metabolite of Venlafaxine; SNRI €125.00

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