Neurotransmitters
Intercellular communication in the central nervous system requires the precise control of the duration and the intensity of neurotransmitter action at the specific receptors. After they have been released at the synapse, neurotransmitters activate pre- and/or postsynaptic receptors. To terminate synaptic transmission, neurotransmitters can, in turn, be inactivated by either enzymatic degradation or active transport into neuronal and/or glial cells by neurotransmitter transporters[1]. Reuptake inhibitors of neurotransmitters have a direct effect on extracellular concentrations of neurotransmitters in the synapses, and therefore influence neurotransmission. Axon Medchem offers inhibitors for a wide range of (monoamine) reuptake inhibitors of high quality.
[1] Neurotransmitter Transporters in the Central Nervous System. J. Masson, C. Sagné, M. Hamon, S. El Mestikawy. Pharm. Rev. 1999, 51, 439-464.
| Axon ID | Name | Description | From price | |
|---|---|---|---|---|
| 3777 | (R)-AS-1 | First-in-class highly selective and orally bioavailable PAM of EAAT2 | €145.00 | |
| 1238 | ALX 5407 hydrochloride | GlyT-1 inhibitor | €140.00 | |
| 1333 | Amoxapine | Tricyclic antidepressant; Potent reuptake inhibitor of norepinephrine (NRI) | €50.00 | |
| 1297 | Atomoxetine hydrochloride | NRI inhibitor | €95.00 | |
| 2099 | Avridine | Lipoidal amine; interferon-inducing and adjuvant properties | €80.00 | |
| 1462 | Azaphen | Antidepressant | €105.00 | |
| 1257 | BTS 54-505 | 5-HT uptake inhibitor | €85.00 | |
| 1451 | Bupropion hydrochloride | DRI and NRI; nicotinic acetylcholine receptor antagonist | €85.00 | |
| 3619 | Chlorphentermine hydrochloride | Serotonin transporter (SERT) substrate | €95.00 | |
| 1320 | Citalopram hydrobromide | SSRI; Antidepressant | €75.00 | |
| 1722 | Deshydroxy Venlafaxine HCl | Metabolite of Venlafaxine; SNRI | €95.00 | |
| 3555 | Desvenlafaxine hydrochloride | Metabolite of Venlafaxine; SNRI | €70.00 | |
| 1726 | Dinorvenlafaxine | Metabolite of Venlafaxine; SNRI | €75.00 | |
| 3881 | ECSI#6 | First uncompetitive serotonin transporter (SERT) inhibitor | €140.00 | |
| 3315 | Escitalopram oxalate | SSRI; Antidepressant | €50.00 | |
| 1302 | Fluoxetine hydrochloride | SSRI | €75.00 | |
| 1556 | Fluvoxamine maleate | SSRI | €50.00 | |
| 1203 | GBR 12783 dihydrochloride | Dopamine uptake inhibitor | €90.00 | |
| 4201 | Iclepertin | Potent, selective and orally active GlyT-1 inhibitor | €240.00 | |
| 3355 | IDT307 | DAT/NET/SERT substrate; Fluorescent dye | €90.00 | |
| 2427 | L-TBOA ammonia salt | Very potent blocker of EAAT1–3 | €135.00 | |
| 2260 | LDN 212320 | Activator of EAAT2 translation; neuroprotectant | €90.00 | |
| 3128 | Levomilnacipran hydrochloride | SNRI | €120.00 | |
| 1139 | LY 393558 | SSRI; 5-HT1B and 5-HT1D antagonist | €125.00 | |
| 2587 | ML352 | Potent and selective inhibitor of the presynaptic choline transporter CHT | €105.00 | |
| 2329 | NS 19504 | Potent activator of large-conductance Ca2+-activated potassium (BK) channels | €90.00 | |
| 3578 | O-Desmethylvenlafaxine | Metabolite of Venlafaxine; SNRI | €70.00 | |
| 2116 | O-Desmethylvenlafaxine succinate | Metabolite of Venlafaxine; SNRI | €90.00 | |
| 1563 | ORG 25935 | GlyT-1 inhibitor | €90.00 | |
| 1452 | Paroxetine hydrochloride | SSRI | €75.00 | |