The presence of cytosolic double-stranded DNA molecules can trigger multiple innate immune signalling pathways which converge on the activation of an ER-resident innate immune adaptor named “STimulator of INterferon Genes (STING)”. STING has been found to mediate type I interferon response downstream of cyclic dinucleotides and a number of DNA and RNA inducing signalling pathway. In addition to its physiological function, a rapidly increasing body of literature highlights the role for STING in human disease where variants of the STING proteins, as well as dysregulated STING signalling, have been implicated in a number of inflammatory diseases. It is evident that activating STING results in the type I interferon response to protect against infection and tumour formation, while dysregulated gain-of-function STING mutations lead to detrimental consequences of autoimmunity[1].

[1] Li et al. Regulating STING in health and disease. J Inflamm (Lond). 2017 Jun 7;14:11.

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Axon ID Name Description From price
3687 ADU-S100 Cyclic dinucleotide (CDN) agonist (activator) of Stimulator of Interferon Genes (STING) Inquire
3688 cGAMP Endogenous agonist for the STING Inquire
3689 E-7766 STING agonist Inquire
3298 MSA-2 Selective and orally available non-nucleotide STING agonist €90.00
3336 SR-717 lithium Non-nucleotide STING agonist €90.00
3673 STING activator C53 Highly potent STING activator €120.00

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