B cell-specific Moloney murine leukemia virus integration site 1 (BMI1) is considered a stem cell factor: a regulator protein of the Polycomb Group of multimeric protein complexes that is reported to regulate the proliferation activity of normal, stem, and progenitor cells[1]. BMI1 plays a role in cell cycle, cell immortalization, and senescence, and is associated with a number of human malignancies where its expression is frequently upregulated. Unfortunately, there is an enormous body of evidence suggesting that increased expression of BMI1 could facilitate chemoresistance, and BMI1 is positively correlated with poor prognosis in cancer patients[2]. In healthy cells, BMI1 controls self-renewal and cell cycle by regulating the tumor suppressor proteins p16INK4a and p14ARF in cells. BMI1 contains a conserved ring finger domain in its N terminal end and a central helix-turn-helix-turn-helix-turn motif (H-T-H-T), which is essential for inducing telomerase activity. Additionally, BMI1 contains two nuclear localization signals, KRRR and KRMK[3].