Mcl-1
The protein Mcl-1 is a member of the BCL-2 family of proteins which have been studied intensively for their importance in the regulation of apoptosis, tumorigenesis and cellular responses to anti-cancer therapy. BCL-2 family members have classically been grouped into three classes. Mcl-1 is a member of the class that inhibits apoptosis (together with BCL-2, BCL-XL, BCL-W, BCL-B (also known as BCL-2L10) and A1 (also known as BCL-2A1)[1].
[1] R.J. Youle, A. Strasser. TheBCL-2 protein family: opposing activities that mediate cell death. Nat. Rev. Mol. Cell Biol. 2008, 9, 47-59.
| Axon ID | Name | Description | From price | |
|---|---|---|---|---|
| 4008 | A-1210477 | Potent and selective inhibitor of MCL-1 | Inquire | |
| 3686 | AMG-176 | Potent and selective Mcl-1 inhibitor | €490.00 | |
| 3731 | AZD5991 | BH3-Groove binding Mcl-1 inhibitor | Inquire | |
| 3713 | MIK665 | BH3-Groove binding Mcl-1 inhibitor | Inquire | |
| 2823 | ML 311 | Potent and selective inhibitor of the protein-protein interaction of Mcl-1 and Bim | €95.00 | |
| 3723 | S63845 | BH3-Groove binding Mcl-1 inhibitor | Inquire | |