Ion Channels

Ion channels are pore-forming membrane proteins that act as gated pathways for the movement of ions across cell membranes. They are found in both surface and intracellular membranes, and play essential roles in the physiology of all cell types. Ion channels are especially prominent components of the nervous system as they underlie the nerve impulse and because "transmitter-activated" channels mediate conduction across the synapses of a nerve cell’s axon. In addition, ion channels are key components in a wide variety of biological processes that involve rapid changes in cells, such as cardiac, skeletal, and smooth-muscle contraction, epithelial transport of nutrients and ions, T-cell activation and pancreatic beta-cell insulin release. Many human diseases are caused by defects in ion channel function, which can lead to disease in a number of different ways: Gain, or loss, of channel function (channel-pathies), defective regulation of channel activity by intracellular or extracellular ligands or by channel modulators, by autoantibodies binding to ion channel proteins, or even by ion channels that act as lethal agents[1]. Ion channels can be categorized based upon multiple characteristics, e.g. their selectivity in permeability for a certain type of ion, the number of pores, or by their mechanism of activation.  The wide range of Axon Ligands™  targeting ion channels has been categorized into ligand gated ion channels and voltage gated ion channels (and more). Categories are subdivided on the basis of their selectivity towards activating ligand or the type of ion. In addition, sections are created for specific members of the family of potassium channels that are characterized by their deviant ways of activation (e.g. calcium-activated, and ATP-sensitive potassium channels).

[1] Taken from Oxford Textbook of Medicine, fifth edition, 2010. ISBN 9780470987261.

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Axon ID Name Description From price
2534 (+)-Azasetron hydrochloride 5-HT3 antagonist €135.00
2535 (-)-Azasetron hydrochloride 5-HT3 antagonist €135.00
2784 (R)-(-)-N-Desmethyl-PK 11195 Radioligand precursor of the benzodiazepine antagonist (R)-(-)-PK 11195 €145.00
2785 (R)-(-)-PK 11195 Benzodiazepine antagonist. €125.00
1816 A 784168 TRPV1 receptor antagonist €95.00
2182 A 804598 Potent and selective P2X7 antagonist €125.00
1504 ABT 102 TRPV1 antagonist €90.00
1097 Alosetron hydrochloride 5-HT3 antagonist €85.00
3356 AMG 9810 Potent and selective vanilloid receptor-1 (TRPV1) antagonist €90.00
3013 Aranidipine Ca2+ channel antagonist €110.00
1096 Azasetron hydrochloride 5-HT3 antagonist €90.00
3335 AZD6765 dihydrochloride Noncompetitive NMDA antagonist €90.00
3295 BIA TMBIM6 antagonist €120.00
2523 BX 430 Allosteric antagonist of human P2X4 receptor channels €105.00
1217 CFM 2 AMPA antagonist €115.00
1200 CNQX AMPA/Kainate antagonist €85.00
2522 CNQX disodium salt AMPA/Kainate antagonist €90.00
2254 CP 101606 NMDA NR2B antagonist €120.00
1406 CP 101606 mesylate NMDA NR2B antagonist €85.00
3323 Diltiazem hydrochloride Ca2+ channel antagonist (L-type voltage gated) €50.00
1201 DNQX AMPA/Kainate antagonist €50.00
1246 Eliprodil NMDA antagonist €90.00
2952 Fantofarone Highly potent and specific Ca2+ channel antagonist €125.00
1437 Flupirtine maleate Analgesic €65.00
1262 Gavestinel NMDA antagonist (glycine site) €110.00
1449 Granisetron hydrochloride 5-HT3 antagonist €80.00
2742 GSK 2193874 Orally active TRPV4 antagonist €120.00
1374 GYKI 53655 AMPA antagonist €85.00
1156 Ifenprodil L-(+)-tartrate NMDA antagonist €55.00
3429 Indophagolin Potent autophagy inhibitor €130.00

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