Ion Channels

Ion channels are pore-forming membrane proteins that act as gated pathways for the movement of ions across cell membranes. They are found in both surface and intracellular membranes, and play essential roles in the physiology of all cell types. Ion channels are especially prominent components of the nervous system as they underlie the nerve impulse and because "transmitter-activated" channels mediate conduction across the synapses of a nerve cell’s axon. In addition, ion channels are key components in a wide variety of biological processes that involve rapid changes in cells, such as cardiac, skeletal, and smooth-muscle contraction, epithelial transport of nutrients and ions, T-cell activation and pancreatic beta-cell insulin release. Many human diseases are caused by defects in ion channel function, which can lead to disease in a number of different ways: Gain, or loss, of channel function (channel-pathies), defective regulation of channel activity by intracellular or extracellular ligands or by channel modulators, by autoantibodies binding to ion channel proteins, or even by ion channels that act as lethal agents[1]. Ion channels can be categorized based upon multiple characteristics, e.g. their selectivity in permeability for a certain type of ion, the number of pores, or by their mechanism of activation.  The wide range of Axon Ligands™  targeting ion channels has been categorized into ligand gated ion channels and voltage gated ion channels (and more). Categories are subdivided on the basis of their selectivity towards activating ligand or the type of ion. In addition, sections are created for specific members of the family of potassium channels that are characterized by their deviant ways of activation (e.g. calcium-activated, and ATP-sensitive potassium channels).

[1] Taken from Oxford Textbook of Medicine, fifth edition, 2010. ISBN 9780470987261.

24 Item(s)

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Axon ID Name Description From price
1077 (+)-Epibatidine dihydrochloride Nicotinic acetylcholine receptor agonist €155.00
1594 (+)-Pagoclone GABAA-α2 and GABAA-α3 agonist €135.00
1078 (-)-Epibatidine dihydrochloride Nicotinic acetylcholine receptor agonist €155.00
1076 (±)-Epibatidine dihydrochloride Nicotinic acetylcholine receptor agonist €95.00
2694 4BP-TQS Allosteric agonist of α7 nAChR €110.00
3415 AMPA Highly selective AMPA receptor agonist €110.00
2401 AT 1001 High affinity and selective α3β4 nAChR ligand with partial agonistic and antagonistic effects €95.00
1153 B-HT 920 dihydrochloride D2 agonist, α2 adrenoceptor agonist; 5-HT3 antagonist €75.00
1604 CP 615003 mesylate GABAA agonist €90.00
2621 GAT107 allosteric agonist and PAM of α7 nAChR €110.00
2860 GTS 21 dihydrochloride Selective α7 nicotinic acetylcholine receptor (nAChR) partial agonist €90.00
3726 JT010 Potent and selective TRPA1 agonist  Recently added €90.00
1196 L 838417 GABAA-α1 antagonist €90.00
3390 L-655,708 Selective inverse agonist of GABAA-α5 €120.00
3640 Loperamide hydrochloride Potent Mu-opioid agonist  Recently added €50.00
2374 Optovin Reversible photoactivated TRPA1 agonist €85.00
2109 PHA 543613 dihydrochloride nAChR agonist (α7 sub-unit selective) €115.00
2908 PNU 282987 hydrochloride nAChR agonist (α7 sub-unit selective) €90.00
1195 SL 651498 GABAA-α2 agonist €80.00
1422 TP 003 GABAA-α3 agonist €80.00
1384 Varenicline dihydrochloride Nicotinic acetylcholine receptor agonist €80.00
2074 Varenicline tartrate Selective α4β2 nicotinic acetylcholine receptor (nAChR) partial agonist €80.00
1646 Zaleplon GABAA-α1 agonist €65.00
1197 Zopiclone Benzodiazepine agonist €70.00

24 Item(s)

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